Myelomonocytic myeloma cell line (LB84-1)

B. G.M. Durie; T. M. Grogan; C. Spier; E. Vela; V. Baum; M. A. Rodriquez; Y. Frutiger

doi:10.1182/blood.v73.3.770.bloodjournal733770

Myelomonocytic myeloma cell line (LB84-1)

B. G.M. Durie, T. M. Grogan, C. Spier, E. Vela, V. Baum, M. A. Rodriquez, Y. Frutiger

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A human cell line (LB 84-1) has been established from the bone marrow of a patient with Bence-Jones myeloma. Coexpression of plasma cell (Leu 17[CD38]) and myelomonocytic antigens (Leu MI[CD15], Leu M5 (CD11c], MY7 [CD13] plus butyrate and chloracetate esterase) proved to be an unusual but sustained feature of this cell line. The plasma cell phenotype with multinuclearity was retained. Shared major chromosomal abnormalities (del [5] [p14], t[5;?] [q35;?], del [6] [q21], and del 7[q32]) between the direct and cell line karyotypes affirmed the LB 84-1 cell as being derived from the original patient myeloma clone. The mechanisms potentially responsible for the aberrant coexpressed phenotype are discussed. This myelomonocytic myeloma cell line will hopefully prove to be a valuable tool for the study of the genotypic and phenotypic evolution of human myeloma.

Original language	English (US)
Pages (from-to)	770-776
Number of pages	7
Journal	Blood
Volume	73
Issue number	3
DOIs	https://doi.org/10.1182/blood.v73.3.770.bloodjournal733770
State	Published - 1989

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "Myelomonocytic myeloma cell line (LB84-1)",

abstract = "A human cell line (LB 84-1) has been established from the bone marrow of a patient with Bence-Jones myeloma. Coexpression of plasma cell (Leu 17[CD38]) and myelomonocytic antigens (Leu MI[CD15], Leu M5 (CD11c], MY7 [CD13] plus butyrate and chloracetate esterase) proved to be an unusual but sustained feature of this cell line. The plasma cell phenotype with multinuclearity was retained. Shared major chromosomal abnormalities (del [5] [p14], t[5;?] [q35;?], del [6] [q21], and del 7[q32]) between the direct and cell line karyotypes affirmed the LB 84-1 cell as being derived from the original patient myeloma clone. The mechanisms potentially responsible for the aberrant coexpressed phenotype are discussed. This myelomonocytic myeloma cell line will hopefully prove to be a valuable tool for the study of the genotypic and phenotypic evolution of human myeloma.",

author = "Durie, {B. G.M.} and Grogan, {T. M.} and C. Spier and E. Vela and V. Baum and Rodriquez, {M. A.} and Y. Frutiger",

year = "1989",

doi = "10.1182/blood.v73.3.770.bloodjournal733770",

language = "English (US)",

volume = "73",

pages = "770--776",

journal = "Blood",

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T1 - Myelomonocytic myeloma cell line (LB84-1)

AU - Durie, B. G.M.

AU - Grogan, T. M.

AU - Spier, C.

AU - Vela, E.

AU - Baum, V.

AU - Rodriquez, M. A.

AU - Frutiger, Y.

PY - 1989

Y1 - 1989

N2 - A human cell line (LB 84-1) has been established from the bone marrow of a patient with Bence-Jones myeloma. Coexpression of plasma cell (Leu 17[CD38]) and myelomonocytic antigens (Leu MI[CD15], Leu M5 (CD11c], MY7 [CD13] plus butyrate and chloracetate esterase) proved to be an unusual but sustained feature of this cell line. The plasma cell phenotype with multinuclearity was retained. Shared major chromosomal abnormalities (del [5] [p14], t[5;?] [q35;?], del [6] [q21], and del 7[q32]) between the direct and cell line karyotypes affirmed the LB 84-1 cell as being derived from the original patient myeloma clone. The mechanisms potentially responsible for the aberrant coexpressed phenotype are discussed. This myelomonocytic myeloma cell line will hopefully prove to be a valuable tool for the study of the genotypic and phenotypic evolution of human myeloma.

AB - A human cell line (LB 84-1) has been established from the bone marrow of a patient with Bence-Jones myeloma. Coexpression of plasma cell (Leu 17[CD38]) and myelomonocytic antigens (Leu MI[CD15], Leu M5 (CD11c], MY7 [CD13] plus butyrate and chloracetate esterase) proved to be an unusual but sustained feature of this cell line. The plasma cell phenotype with multinuclearity was retained. Shared major chromosomal abnormalities (del [5] [p14], t[5;?] [q35;?], del [6] [q21], and del 7[q32]) between the direct and cell line karyotypes affirmed the LB 84-1 cell as being derived from the original patient myeloma clone. The mechanisms potentially responsible for the aberrant coexpressed phenotype are discussed. This myelomonocytic myeloma cell line will hopefully prove to be a valuable tool for the study of the genotypic and phenotypic evolution of human myeloma.

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JO - Blood

JF - Blood

IS - 3

ER -

Myelomonocytic myeloma cell line (LB84-1)

Abstract

ASJC Scopus subject areas

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