Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

Maham Farshidpour, Monjur Ahmed, Shilpa Junna, Juanita L. Merchant

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalWorld Journal of Gastrointestinal Oncology
Volume13
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • Gastrointestinal cancers
  • Immune checkpoint inhibitors
  • Myeloid-derived suppressor cells
  • Tumor progression

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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