Musculoskeletal and CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report

Jacob Denton; Hasan Ozgur; Pantea Sazegar; John Galgiani; Talha Riaz

doi:10.1016/j.idcr.2024.e02021

Musculoskeletal and CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report

Jacob Denton, Hasan Ozgur, Pantea Sazegar, John Galgiani, Talha Riaz

Research output: Contribution to journal › Article › peer-review

Abstract

We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated Coccidioides infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for Coccidioides infection in immunosuppressed patients living in endemic areas.

Original language	English (US)
Article number	e02021
Journal	IDCases
Volume	37
DOIs	https://doi.org/10.1016/j.idcr.2024.e02021
State	Published - Jan 2024
Externally published	Yes

Keywords

CNS fungal infections
Coccidioides
Fingolimod
Multiple sclerosis

ASJC Scopus subject areas

Infectious Diseases

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10.1016/j.idcr.2024.e02021

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title = "Musculoskeletal and CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report",

abstract = "We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated Coccidioides infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for Coccidioides infection in immunosuppressed patients living in endemic areas.",

keywords = "CNS fungal infections, Coccidioides, Fingolimod, Multiple sclerosis",

author = "Jacob Denton and Hasan Ozgur and Pantea Sazegar and John Galgiani and Talha Riaz",

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language = "English (US)",

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AU - Denton, Jacob

AU - Ozgur, Hasan

AU - Sazegar, Pantea

AU - Galgiani, John

AU - Riaz, Talha

PY - 2024/1

Y1 - 2024/1

N2 - We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated Coccidioides infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for Coccidioides infection in immunosuppressed patients living in endemic areas.

AB - We report the case of a 56-year-old female with a past medical history of multiple sclerosis on disease-modifying therapy of fingolimod who presented with disseminated Coccidioides infection, initially of the ankles bilaterally before progressing to the central nervous system. CNS coccidiomycosis has thus far not been associated with any pharmacological therapy for multiple sclerosis. Clinicians should have a high degree of suspicion for Coccidioides infection in immunosuppressed patients living in endemic areas.

KW - CNS fungal infections

KW - Coccidioides

KW - Fingolimod

KW - Multiple sclerosis

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SN - 2214-2509

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JO - IDCases

JF - IDCases

M1 - e02021

ER -

Musculoskeletal and CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report

Abstract

Keywords

ASJC Scopus subject areas

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