Muscle assembly: A titanic achievement?

Carol C. Gregorio, Henk Granzier, Hiroyuki Sorimachi, Siegfried Labeit

Research output: Contribution to journalArticlepeer-review

272 Scopus citations


The formation of perfectly aligned myofibrils in striated muscle represents a dramatic example of supramolecular assembly in eukaryotic cells. Recently, considerable progress has been made in deciphering the roles that titin, the third most abundant protein in muscle, has in this process. An increasing number of sarcomeric proteins (ligands) are being identified that bind to specific titin domains. Titin may serve as a molecular blueprint for sarcomere assembly and turnover by specifying the precise position of its ligands within each half-sarcomere in addition to functioning as a molecular spring that maintains the structural integrity of the contracting myofibrils.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 1 1999

ASJC Scopus subject areas

  • Cell Biology


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