@article{f83f7115a9684bf6bbd14ebd34fc3f16,
title = "Muscle assembly: A titanic achievement?",
abstract = "The formation of perfectly aligned myofibrils in striated muscle represents a dramatic example of supramolecular assembly in eukaryotic cells. Recently, considerable progress has been made in deciphering the roles that titin, the third most abundant protein in muscle, has in this process. An increasing number of sarcomeric proteins (ligands) are being identified that bind to specific titin domains. Titin may serve as a molecular blueprint for sarcomere assembly and turnover by specifying the precise position of its ligands within each half-sarcomere in addition to functioning as a molecular spring that maintains the structural integrity of the contracting myofibrils.",
author = "Gregorio, {Carol C.} and Henk Granzier and Hiroyuki Sorimachi and Siegfried Labeit",
note = "Funding Information: We especially thank Thomas Centner for the illustrations. We also thank the many members of our (past and present) laboratories especially Bernhard Kolmerer, Karoly Trombit{\'a}s, and Thomas Centner who have made critical contributions, both scientifically and intellectually, to the development of this review. Work in our laboratories is supported by grants from the Human Frontier Science Program (Carol Gregorio, Hiroyuki Sorimachi, Siegfried Labeit), National Institutes of Health HL57461 (Carol Gregorio), National Institutes of Health HL61497 (Henk Granzier), the Deutsche Forschungsgemeinschaft (La668/2-3 and La668/3-3) and the Forschungsfond f{\"u}r Klinische Medizin Mannheim (Siegfried Labeit). ",
year = "1999",
month = feb,
day = "1",
doi = "10.1016/S0955-0674(99)80003-9",
language = "English (US)",
volume = "11",
pages = "18--25",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Ltd",
number = "1",
}