Murine model for colitis-associated cancer of the colon

Ashley J. Snider; Agnieszka B. Bialkowska; Amr M. Ghaleb; Vincent W. Yang; Lina M. Obeid; Yusuf A. Hannun

doi:10.1007/978-1-4939-3661-8_14

Murine model for colitis-associated cancer of the colon

Ashley J. Snider, Agnieszka B. Bialkowska, Amr M. Ghaleb, Vincent W. Yang, Lina M. Obeid, Yusuf A. Hannun

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.

Original language	English (US)
Pages (from-to)	245-254
Number of pages	10
Journal	Methods in Molecular Biology
Volume	1438
DOIs	https://doi.org/10.1007/978-1-4939-3661-8_14
State	Published - May 1 2016
Externally published	Yes

Keywords

AOM/DSS model
Azoxymethane
Colitis-associated cancer
Dextran sulphate sodium
Inflammatory bowel disease
Murine model

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/978-1-4939-3661-8_14

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title = "Murine model for colitis-associated cancer of the colon",

abstract = "Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn{\textquoteright}s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.",

keywords = "AOM/DSS model, Azoxymethane, Colitis-associated cancer, Dextran sulphate sodium, Inflammatory bowel disease, Murine model",

author = "Snider, {Ashley J.} and Bialkowska, {Agnieszka B.} and Ghaleb, {Amr M.} and Yang, {Vincent W.} and Obeid, {Lina M.} and Hannun, {Yusuf A.}",

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doi = "10.1007/978-1-4939-3661-8_14",

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T1 - Murine model for colitis-associated cancer of the colon

AU - Snider, Ashley J.

AU - Bialkowska, Agnieszka B.

AU - Ghaleb, Amr M.

AU - Yang, Vincent W.

AU - Obeid, Lina M.

AU - Hannun, Yusuf A.

N1 - Publisher Copyright: © Springer Science+Business Media New York 2016.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.

AB - Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.

KW - AOM/DSS model

KW - Azoxymethane

KW - Colitis-associated cancer

KW - Dextran sulphate sodium

KW - Inflammatory bowel disease

KW - Murine model

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VL - 1438

SP - 245

EP - 254

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

ER -

Murine model for colitis-associated cancer of the colon

Abstract

Keywords

ASJC Scopus subject areas

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