Murine model for colitis-associated cancer of the colon

Ashley J. Snider, Agnieszka B. Bialkowska, Amr M. Ghaleb, Vincent W. Yang, Lina M. Obeid, Yusuf A. Hannun

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalMethods in Molecular Biology
Volume1438
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • AOM/DSS model
  • Azoxymethane
  • Colitis-associated cancer
  • Dextran sulphate sodium
  • Inflammatory bowel disease
  • Murine model

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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