Multislice breath-hold spiral magnetic resonance coronary angiography in patients with coronary artery disease: Effect of intravascular contrast medium

Patrick R. Knuesel, Daniel Nanz, Ursula Wolfensberger, Manojkumar Saranathan, Anja Lehning, Thomas F. Luescher, Borut Marincek, Gustav K. Von Schulthess, Juerg Schwitter

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Purpose: First, to apply a breath-hold multislice 2D spiral magnetic resonance (MR) approach in patients acquiring within 16 heartbeats (acquisition window, 116 msec) a 10-mm-thick stack of four slices (resolution, 1.3 × 1.3 mm2); and second, to evaluate the effect of an intravascular Fe-based contrast medium (CM) on a signal-to-noise ratio (SNR) and a contrast-to-noise ratio (CNR). Materials and Methods: In each patient one or two coronary arteries were imaged prior to and following cumulative doses of 0.25, 0.5, and 0.75 mg of Fe/kg of body weight (bw) of an intravascular CM (CLARISCAN™, Nycomed-Amersham, Princeton, NJ, USA) containing ultrasmall superparamagnetic iron oxide (USPIO) particles. Results: On precontrast maximum intensity projection (MIP) images generated from the stack of slices, 10 and 11 stenoses of 12 stenoses confirmed by coronary angiography were detected by readers 1 and 2, respectively. SNR and CNR in the coronary arteries peaked at 0.50 mg of Fe/kg of bw, yielding a slight increase of 15.5% and 18.4%, respectively (P < 0.05 vs. precontrast), which did not improve detection of coronary artery stenoses. Conclusion: The presented multislice spiral approach allows display of coronary anatomy in MIP formats for convenient display of coronary stenoses. The pulse sequence did not benefit from an intravascular USPIO-based CM, since little improvement in SNR and CNR was achieved.

Original languageEnglish (US)
Pages (from-to)660-667
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume16
Issue number6
DOIs
StatePublished - Dec 2002
Externally publishedYes

Keywords

  • Coronary artery disease
  • Intravascular contrast medium
  • Magnetic resonance coronary angiography
  • Spiral MR imaging
  • Ultrasmall superparamagnetic iron oxide crystals

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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