Abstract
The six loci, β-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 1 lp in the order: CAT-CAL-PTH-HBBC-(HRASl-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRASl-INS); however, the order of the last two tightly linked loci is still not clear.
Original language | English (US) |
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Pages (from-to) | 94-101 |
Number of pages | 8 |
Journal | Human Heredity |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - 1987 |
Externally published | Yes |
Keywords
- 11p
- CAL
- CAT
- Chromosome 11
- HBBC
- HRAS1
- INS
- Linkage
- Multipoint mapping
- PTH
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)