Multipoint mapping studies of six loci on chromosome 11

Deborah A. Meyers; T. H. Beaty; N. E. Maestri; S. D. Kittur; S. E. Antonarakis; H. H. Kazazian

doi:10.1159/000153683

Multipoint mapping studies of six loci on chromosome 11

Deborah A. Meyers, T. H. Beaty, N. E. Maestri, S. D. Kittur, S. E. Antonarakis, H. H. Kazazian

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The six loci, β-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 1 lp in the order: CAT-CAL-PTH-HBBC-(HRASl-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRASl-INS); however, the order of the last two tightly linked loci is still not clear.

Original language	English (US)
Pages (from-to)	94-101
Number of pages	8
Journal	Human Heredity
Volume	37
Issue number	2
DOIs	https://doi.org/10.1159/000153683
State	Published - 1987
Externally published	Yes

Keywords

11p
CAL
CAT
Chromosome 11
HBBC
HRAS1
INS
Linkage
Multipoint mapping
PTH

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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@article{0b9a305029994059b1617cf0e48f40cb,

title = "Multipoint mapping studies of six loci on chromosome 11",

abstract = "The six loci, β-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 1 lp in the order: CAT-CAL-PTH-HBBC-(HRASl-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRASl-INS); however, the order of the last two tightly linked loci is still not clear.",

keywords = "11p, CAL, CAT, Chromosome 11, HBBC, HRAS1, INS, Linkage, Multipoint mapping, PTH",

author = "Meyers, {Deborah A.} and Beaty, {T. H.} and Maestri, {N. E.} and Kittur, {S. D.} and Antonarakis, {S. E.} and Kazazian, {H. H.}",

year = "1987",

doi = "10.1159/000153683",

language = "English (US)",

volume = "37",

pages = "94--101",

journal = "Human Heredity",

issn = "0001-5652",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Multipoint mapping studies of six loci on chromosome 11

AU - Meyers, Deborah A.

AU - Beaty, T. H.

AU - Maestri, N. E.

AU - Kittur, S. D.

AU - Antonarakis, S. E.

AU - Kazazian, H. H.

PY - 1987

Y1 - 1987

N2 - The six loci, β-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 1 lp in the order: CAT-CAL-PTH-HBBC-(HRASl-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRASl-INS); however, the order of the last two tightly linked loci is still not clear.

AB - The six loci, β-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 1 lp in the order: CAT-CAL-PTH-HBBC-(HRASl-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRASl-INS); however, the order of the last two tightly linked loci is still not clear.

KW - 11p

KW - CAL

KW - CAT

KW - Chromosome 11

KW - HBBC

KW - HRAS1

KW - INS

KW - Linkage

KW - Multipoint mapping

KW - PTH

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U2 - 10.1159/000153683

DO - 10.1159/000153683

M3 - Article

C2 - 3294571

AN - SCOPUS:0023090916

SN - 0001-5652

VL - 37

SP - 94

EP - 101

JO - Human Heredity

JF - Human Heredity

IS - 2

ER -

Multipoint mapping studies of six loci on chromosome 11

Abstract

Keywords

ASJC Scopus subject areas

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