Multiplexed and continuous microfluidic sensors using dynamic complex droplets

Baishali Barua, Tyler J. Durkin, Isabel M. Beeley, Aakanksha Gadh, Suchol Savagatrup

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Emissive complex droplets with reconfigurable morphology and dynamic optical properties offer exciting opportunities as chemical sensors due to their stimuli-responsive characteristics. In this work, we demonstrated a real-time optical sensing platform that combines poly(dimethylsiloxane) (PDMS) microfluidics and complex droplets as sensing materials. We utilized a mechanism, called directional emission, to transduce changes in interfacial tension into optical signals. We discuss the fabrication and integration of PDMS microfluidics with complex emulsions to facilitate continuous measurement of fluorescent emission and, ultimately, the interfacial tensions. Furthermore, by varying the interfacial functionalization and fluorescent dye with characteristic wavelength, we generate multiple formulations of droplets and obtain differential responses to stimuli that alter interfacial tensions (i.e., composition of surfactants, pH). Our results illustrate a proof-of-concept multiplexed and continuous sensing platform with potential applications in miniaturized, on-site environmental monitoring and biosensing.

Original languageEnglish (US)
Pages (from-to)1930-1940
Number of pages11
JournalSoft Matter
Issue number10
StatePublished - Feb 21 2023
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics

Cite this