Multiple‐hole approach to zero‐order release

Wei‐Youh ‐Y Kuu; Samuel H. Yalkowsky

doi:10.1002/jps.2600740904

Multiple‐hole approach to zero‐order release

Wei‐Youh ‐Y Kuu, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We describe an approach to zero‐order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero‐order release is attained by using the proper density and configuration of holes on the surface of the device.

Original language	English (US)
Pages (from-to)	926-933
Number of pages	8
Journal	Journal of pharmaceutical sciences
Volume	74
Issue number	9
DOIs	https://doi.org/10.1002/jps.2600740904
State	Published - Sep 1985

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600740904

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title = "Multiple‐hole approach to zero‐order release",

abstract = "We describe an approach to zero‐order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero‐order release is attained by using the proper density and configuration of holes on the surface of the device.",

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year = "1985",

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AB - We describe an approach to zero‐order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero‐order release is attained by using the proper density and configuration of holes on the surface of the device.

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Multiple‐hole approach to zero‐order release

Abstract

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