Multiple‐hole approach to zero‐order release

Wei‐Youh ‐Y Kuu, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We describe an approach to zero‐order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero‐order release is attained by using the proper density and configuration of holes on the surface of the device.

Original languageEnglish (US)
Pages (from-to)926-933
Number of pages8
JournalJournal of pharmaceutical sciences
Issue number9
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Pharmaceutical Science


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