TY - JOUR
T1 - Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer
AU - Lambert-Messerlian, G. M.
AU - Steinhoff, M.
AU - Zheng, W.
AU - Canick, J. A.
AU - Gajewski, W. H.
AU - Seifer, D. B.
AU - Schneyer, A. L.
PY - 1997/6
Y1 - 1997/6
N2 - Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.
AB - Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.
UR - http://www.scopus.com/inward/record.url?scp=0031172116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031172116&partnerID=8YFLogxK
U2 - 10.1006/gyno.1997.4719
DO - 10.1006/gyno.1997.4719
M3 - Article
C2 - 9190984
AN - SCOPUS:0031172116
SN - 0090-8258
VL - 65
SP - 512
EP - 516
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -