Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

Mikhail Kondrashov; Samuel P.S. Svensson; Peter Ström; Andreas Westermark; Hanna Jacobson-Ingemyr; Akihiro Takano; Lenke Tari; Miklós Tóth; Minying Cai; Victor J. Hruby; Magnus Schou

doi:10.1021/acs.bioconjchem.0c00671

Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

Mikhail Kondrashov, Samuel P.S. Svensson, Peter Ström, Andreas Westermark, Hanna Jacobson-Ingemyr, Akihiro Takano, Lenke Tari, Miklós Tóth, Minying Cai, Victor J. Hruby, Magnus Schou

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

Original language	English (US)
Pages (from-to)	497-501
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	32
Issue number	3
DOIs	https://doi.org/10.1021/acs.bioconjchem.0c00671
State	Published - Mar 17 2021

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

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title = "Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma",

abstract = "A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.",

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year = "2021",

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doi = "10.1021/acs.bioconjchem.0c00671",

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T1 - Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

AU - Kondrashov, Mikhail

AU - Svensson, Samuel P.S.

AU - Ström, Peter

AU - Westermark, Andreas

AU - Jacobson-Ingemyr, Hanna

AU - Takano, Akihiro

AU - Tari, Lenke

AU - Tóth, Miklós

AU - Cai, Minying

AU - Hruby, Victor J.

AU - Schou, Magnus

PY - 2021/3/17

Y1 - 2021/3/17

N2 - A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

AB - A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

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JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 3

ER -

Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

Abstract

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