Abstract
The multidrug and toxin extrusion (MATE) family of transporters plays a central role in clearing the body of cationic, xenobiotic compounds. Expressed principally in the kidney and liver, they mediate the active step in renal and hepatic secretion of a wide array of clinically important drugs. This chapter provides an overview of the cellular and organ level physiology of organic cation (OC) secretion, thereby establishing the "physiological fingerprint" of the process currently believed to be mediated by MATE family members. It discusses characteristics of MATE-mediated transport, including sites of expression, mechanism of action, and selectivity. The molecular characteristics of MATE proteins are then described, including issues pertaining to their structure, genetic diversity, and regulation of expression. The chapter explains the influence of MATE proteins on renal drug clearance.
| Original language | English (US) |
|---|---|
| Title of host publication | Drug Transporters |
| Subtitle of host publication | Molecular Characterization and Role in Drug Disposition: Second Edition |
| Publisher | Wiley-Blackwell |
| Pages | 223-243 |
| Number of pages | 21 |
| Volume | 9781118489932 |
| ISBN (Electronic) | 9781118705308 |
| ISBN (Print) | 9781118489932 |
| DOIs | |
| State | Published - Sep 2 2014 |
Keywords
- Molecular characteristics
- Multidrug and toxin extrusion (MATE)
- Organic cation (OC) secretion
- Renal drug clearance
- Subcellular distribution
ASJC Scopus subject areas
- General Chemistry
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology
- General Medicine