Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: How many genetic subgroups are there?

Jo Vandesompele, Frank Speleman, Nadine Van Roy, Genevi Ve Laureys, Christian Brinkschmidt, Holger Christiansen, Fritz Lampert, Maria Lastowska, Nick Bown, Andy Pearson, James C. Nicholson, Fiona Ross, Val Rie Combaret, Olivier Delattre, Bert G. Feuerstein, Dominique Plantaz

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Procedure. Analysis of comparative genomic hybridization (CGH) data of 120 tumors from four different studies, and data of 84 previously unpublished tumors, allowed delineation of at least six different genetic subsets of neuroblastomas. Results and Conclusions. A small number of tumors show no detectable imbalances. A second group of tumors presents with gains and losses of whole chromosomes and is found predominantly in prognostically favorable stage 1 and 2 tumors. The remaining groups are characterized by the presence of partial chromosome imbalances, and are found mostly in stage 3, 4, and 4S tumors. The third group shows 17q gain without 11q loss, 1p loss, or MYCN amplification (MNA). The fourth group has 1p deletion or MNA, and finally, a fifth group shows 11q loss without 1p deletion or MNA, and is found mainly in stage 4 tumors. The latter group is significantly associated with losses of 3p, 4p, and 14q.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalMedical and Pediatric Oncology
Volume36
Issue number1
DOIs
StatePublished - 2001

Keywords

  • CGH
  • Genetic subgroup
  • Neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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