Multi-pinhole SPECT imaging with silicon strip detectors

Todd E. Peterson; Sepideh Shokouhi; Lars R. Furenlid; Donald W. Wilson

doi:10.1109/TNS.2009.2012514

Multi-pinhole SPECT imaging with silicon strip detectors

Todd E. Peterson, Sepideh Shokouhi, Lars R. Furenlid, Donald W. Wilson

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Silicon double-sided strip detectors offer outstanding instrinsic spatial resolution with reasonable detection efficiency for iodine-125 emissions. This spatial resolution allows for multiple-pinhole imaging at low magnification, minimizing the problem of multiplexing. We have conducted imaging studies using a prototype system that utilizes a detector of 300-micrometer thickness and 50-micrometer strip pitch together with a 23-pinhole collimator. These studies include an investigation of the synthetic-collimator imaging approach, which combines multiple-pinhole projections acquired at multiple magnifications to obtain tomographic reconstructions from limited-angle data using the ML-EM algorithm. Sub-millimeter spatial resolution was obtained, demonstrating the basic validity of this approach.

Original language	English (US)
Article number	5076105
Pages (from-to)	646-652
Number of pages	7
Journal	IEEE Transactions on Nuclear Science
Volume	56
Issue number	3
DOIs	https://doi.org/10.1109/TNS.2009.2012514
State	Published - Jun 2009

Keywords

Biomedical nuclear imaging
Microstrip detectors,silicon radiation detectors
SPECTinstrumentation
Small animal imagers

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

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10.1109/TNS.2009.2012514

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title = "Multi-pinhole SPECT imaging with silicon strip detectors",

abstract = "Silicon double-sided strip detectors offer outstanding instrinsic spatial resolution with reasonable detection efficiency for iodine-125 emissions. This spatial resolution allows for multiple-pinhole imaging at low magnification, minimizing the problem of multiplexing. We have conducted imaging studies using a prototype system that utilizes a detector of 300-micrometer thickness and 50-micrometer strip pitch together with a 23-pinhole collimator. These studies include an investigation of the synthetic-collimator imaging approach, which combines multiple-pinhole projections acquired at multiple magnifications to obtain tomographic reconstructions from limited-angle data using the ML-EM algorithm. Sub-millimeter spatial resolution was obtained, demonstrating the basic validity of this approach.",

keywords = "Biomedical nuclear imaging, Microstrip detectors,silicon radiation detectors, SPECTinstrumentation, Small animal imagers",

author = "Peterson, {Todd E.} and Sepideh Shokouhi and Furenlid, {Lars R.} and Wilson, {Donald W.}",

note = "Funding Information: Manuscript received August 10, 2006; revised June 30, 2008, October 07, 2008, and December 02, 2008. Current version published June 10, 2009. This work was supported in part by NIH/NIBIB under Grants R33 EB000776 and P41 EB002035. This work of T. E. Peterson was supported in part by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.",

year = "2009",

month = jun,

doi = "10.1109/TNS.2009.2012514",

language = "English (US)",

volume = "56",

pages = "646--652",

journal = "IEEE Transactions on Nuclear Science",

issn = "0018-9499",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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AU - Peterson, Todd E.

AU - Shokouhi, Sepideh

AU - Furenlid, Lars R.

AU - Wilson, Donald W.

N1 - Funding Information: Manuscript received August 10, 2006; revised June 30, 2008, October 07, 2008, and December 02, 2008. Current version published June 10, 2009. This work was supported in part by NIH/NIBIB under Grants R33 EB000776 and P41 EB002035. This work of T. E. Peterson was supported in part by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.

PY - 2009/6

Y1 - 2009/6

N2 - Silicon double-sided strip detectors offer outstanding instrinsic spatial resolution with reasonable detection efficiency for iodine-125 emissions. This spatial resolution allows for multiple-pinhole imaging at low magnification, minimizing the problem of multiplexing. We have conducted imaging studies using a prototype system that utilizes a detector of 300-micrometer thickness and 50-micrometer strip pitch together with a 23-pinhole collimator. These studies include an investigation of the synthetic-collimator imaging approach, which combines multiple-pinhole projections acquired at multiple magnifications to obtain tomographic reconstructions from limited-angle data using the ML-EM algorithm. Sub-millimeter spatial resolution was obtained, demonstrating the basic validity of this approach.

AB - Silicon double-sided strip detectors offer outstanding instrinsic spatial resolution with reasonable detection efficiency for iodine-125 emissions. This spatial resolution allows for multiple-pinhole imaging at low magnification, minimizing the problem of multiplexing. We have conducted imaging studies using a prototype system that utilizes a detector of 300-micrometer thickness and 50-micrometer strip pitch together with a 23-pinhole collimator. These studies include an investigation of the synthetic-collimator imaging approach, which combines multiple-pinhole projections acquired at multiple magnifications to obtain tomographic reconstructions from limited-angle data using the ML-EM algorithm. Sub-millimeter spatial resolution was obtained, demonstrating the basic validity of this approach.

KW - Biomedical nuclear imaging

KW - Microstrip detectors,silicon radiation detectors

KW - SPECTinstrumentation

KW - Small animal imagers

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JF - IEEE Transactions on Nuclear Science

IS - 3

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ER -

Multi-pinhole SPECT imaging with silicon strip detectors

Abstract

Keywords

ASJC Scopus subject areas

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