@inproceedings{dbaf055368f642a783625c6bf03a0643,
title = "Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model",
abstract = "Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.",
keywords = "DMBA, VCD, fluorescence microscopy, multi photon microscopy, optical coherence tomography, optical imaging, ovarian cancer, post-menopausal mouse model, second harmonic generation",
author = "Watson, {Jennifer M.} and Rice, {Photini Faith} and Marion, {Samuel L.} and Bentley, {David L.} and Brewer, {Molly A.} and Urs Utzinger and Hoyer, {Patricia B.} and Barton, {Jennifer K.}",
year = "2011",
doi = "10.1117/12.875577",
language = "English (US)",
isbn = "9780819484277",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Advanced Biomedical and Clinical Diagnostic Systems IX",
note = "Advanced Biomedical and Clinical Diagnostic Systems IX ; Conference date: 23-01-2011 Through 25-01-2011",
}