MSP dynamics and retraction in nematode sperm

Charles W. Wolgemuth

doi:10.1063/1.1900401

MSP dynamics and retraction in nematode sperm

Charles W. Wolgemuth

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Most eukaryotic cells can crawl over surfaces. In general, this motility requires three distinct actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent in vitro experiments with extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generated by depolymerization of the Major Sperm Protein (MSP) cytoskeleton. Combining polymer entropy with a simple kinetic model for disassembly I propose a model for disassembly-induced retraction that fit the in vitro experimental data. This model explains the mechanism by which deconstruction of the cytoskeleton produces the force necessary to pull the cell body forward and suggest further experiments that can test the validity of the model.

Original language	English (US)
Pages (from-to)	145-152
Number of pages	8
Journal	AIP Conference Proceedings
Volume	755
DOIs	https://doi.org/10.1063/1.1900401
State	Published - Mar 31 2005
Event	International Symposium on Interdisciplinary Science, ISIS - Natchitoches, LA, United States Duration: Oct 6 2004 → Oct 8 2004

Keywords

Cell motility
Gel
MSP
Major sperm protein
Mathematical model

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.1900401

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title = "MSP dynamics and retraction in nematode sperm",

abstract = "Most eukaryotic cells can crawl over surfaces. In general, this motility requires three distinct actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent in vitro experiments with extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generated by depolymerization of the Major Sperm Protein (MSP) cytoskeleton. Combining polymer entropy with a simple kinetic model for disassembly I propose a model for disassembly-induced retraction that fit the in vitro experimental data. This model explains the mechanism by which deconstruction of the cytoskeleton produces the force necessary to pull the cell body forward and suggest further experiments that can test the validity of the model.",

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AU - Wolgemuth, Charles W.

PY - 2005/3/31

Y1 - 2005/3/31

N2 - Most eukaryotic cells can crawl over surfaces. In general, this motility requires three distinct actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent in vitro experiments with extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generated by depolymerization of the Major Sperm Protein (MSP) cytoskeleton. Combining polymer entropy with a simple kinetic model for disassembly I propose a model for disassembly-induced retraction that fit the in vitro experimental data. This model explains the mechanism by which deconstruction of the cytoskeleton produces the force necessary to pull the cell body forward and suggest further experiments that can test the validity of the model.

AB - Most eukaryotic cells can crawl over surfaces. In general, this motility requires three distinct actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent in vitro experiments with extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generated by depolymerization of the Major Sperm Protein (MSP) cytoskeleton. Combining polymer entropy with a simple kinetic model for disassembly I propose a model for disassembly-induced retraction that fit the in vitro experimental data. This model explains the mechanism by which deconstruction of the cytoskeleton produces the force necessary to pull the cell body forward and suggest further experiments that can test the validity of the model.

KW - Cell motility

KW - Gel

KW - MSP

KW - Major sperm protein

KW - Mathematical model

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DO - 10.1063/1.1900401

M3 - Conference article

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VL - 755

SP - 145

EP - 152

JO - AIP Conference Proceedings

JF - AIP Conference Proceedings

T2 - International Symposium on Interdisciplinary Science, ISIS

Y2 - 6 October 2004 through 8 October 2004

ER -

MSP dynamics and retraction in nematode sperm

Abstract

Keywords

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