TY - JOUR
T1 - MR elastography frequency–dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects
AU - Lv, Han
AU - Kurt, Mehmet
AU - Zeng, Na
AU - Ozkaya, Efe
AU - Marcuz, Fabiola
AU - Wu, Lyndia
AU - Laksari, Kaveh
AU - Camarillo, David B.
AU - Pauly, Kim Butts
AU - Wang, Zhenchang
AU - Wintermark, Max
N1 - Funding Information:
We thank Richard L. Ehman from the Mayo Clinic Rochester for providing the MRE activation device. We acknowledge Karla Epperson, Kevin Epperson, and Anne M. Sawyer from the Richard M. Lucas Center, Stanford University for their support during the experiments.
Funding Information:
This work was supported by Grant No. 61801311 from the National Natural Science Foundation of China, Grant No. 7182044 from Beijing Natural Science Foundation, No. PX2018001 from Beijing Hospitals Authority, QML20180103 from Beijing Hospitals Authority Youth Programme, No. YYZZ2017B01 from Beijing Friendship Hospital, Capital Medical University, and No. 2019 M660717 from China Postdoctoral Science Foundation. Acknowledgments
Publisher Copyright:
© 2020, European Society of Radiology.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Objectives: To analyze the mechanical properties in different regions of the brain in healthy adults in a wide age range: 26 to 76 years old. Methods: We used a multifrequency magnetic resonance elastography (MRE) protocol to analyze the effect of age on frequency-dependent (storage and loss moduli, G′ and G″, respectively) and frequency-independent parameters (μ1, μ2, and η, as determined by a standard linear solid model) of the cerebral parenchyma, cortical gray matter (GM), white matter (WM), and subcortical GM structures of 46 healthy male and female subjects. The multifrequency behavior of the brain and frequency-independent parameters were analyzed across different age groups. Results: The annual change rate ranged from − 0.32 to − 0.36% for G′ and − 0.43 to − 0.55% for G″ for the cerebral parenchyma, cortical GM, and WM. For the subcortical GM, changes in G′ ranged from − 0.18 to − 0.23%, and G″ changed − 0.43%. Interestingly, males exhibited decreased elasticity, while females exhibited decreased viscosity with respect to age in some regions of subcortical GM. Significantly decreased values were also found in subjects over 60 years old. Conclusion: Values of G′ and G″ at 60 Hz and the frequency-independent μ2 of the caudate, putamen, and thalamus may serve as parameters that characterize the aging effect on the brain. The decrease in brain stiffness accelerates in elderly subjects. Key Points: • We used a multifrequency MRE protocol to assess changes in the mechanical properties of the brain with age. • Frequency-dependent (storage moduli G′ and loss moduli G″) and frequency-independent (μ1, μ2, and η) parameters can bequantitatively measured by our protocol. • The decreased value of viscoelastic properties due to aging varies in different regions of subcortical GM in males and females, and the decrease in brain stiffness is accelerated in elderly subjects over 60 years old.
AB - Objectives: To analyze the mechanical properties in different regions of the brain in healthy adults in a wide age range: 26 to 76 years old. Methods: We used a multifrequency magnetic resonance elastography (MRE) protocol to analyze the effect of age on frequency-dependent (storage and loss moduli, G′ and G″, respectively) and frequency-independent parameters (μ1, μ2, and η, as determined by a standard linear solid model) of the cerebral parenchyma, cortical gray matter (GM), white matter (WM), and subcortical GM structures of 46 healthy male and female subjects. The multifrequency behavior of the brain and frequency-independent parameters were analyzed across different age groups. Results: The annual change rate ranged from − 0.32 to − 0.36% for G′ and − 0.43 to − 0.55% for G″ for the cerebral parenchyma, cortical GM, and WM. For the subcortical GM, changes in G′ ranged from − 0.18 to − 0.23%, and G″ changed − 0.43%. Interestingly, males exhibited decreased elasticity, while females exhibited decreased viscosity with respect to age in some regions of subcortical GM. Significantly decreased values were also found in subjects over 60 years old. Conclusion: Values of G′ and G″ at 60 Hz and the frequency-independent μ2 of the caudate, putamen, and thalamus may serve as parameters that characterize the aging effect on the brain. The decrease in brain stiffness accelerates in elderly subjects. Key Points: • We used a multifrequency MRE protocol to assess changes in the mechanical properties of the brain with age. • Frequency-dependent (storage moduli G′ and loss moduli G″) and frequency-independent (μ1, μ2, and η) parameters can bequantitatively measured by our protocol. • The decreased value of viscoelastic properties due to aging varies in different regions of subcortical GM in males and females, and the decrease in brain stiffness is accelerated in elderly subjects over 60 years old.
KW - Brain
KW - Elasticity
KW - Magnetic resonance elastography
KW - Neuroimaging
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U2 - 10.1007/s00330-020-07054-7
DO - 10.1007/s00330-020-07054-7
M3 - Article
C2 - 32683552
AN - SCOPUS:85088496580
VL - 30
SP - 6614
EP - 6623
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 12
ER -