Mouse models of DNA polymerases

Miriam R. Menezes, Joann B. Sweasy

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

In 1956, Arthur Kornberg discovered the mechanism of the biological synthesis of DNA and was awarded the Nobel Prize in Physiology or Medicine in 1959 for this contribution, which included the isolation and characterization of Escherichia coli DNA polymerase I. Now there are 15 known DNA polymerases in mammalian cells that belong to four different families. These DNA polymerases function in many different cellular processes including DNA replication, DNA repair, and damage tolerance. Several biochemical and cell biological studies have provoked a further investigation of DNA polymerase function using mouse models in which polymerase genes have been altered using gene-targeting techniques. The phenotypes of mice harboring mutant alleles reveal the prominent role of DNA polymerases in embryogenesis, prevention of premature aging, and cancer suppression.

Original languageEnglish (US)
Pages (from-to)645-665
Number of pages21
JournalEnvironmental and Molecular Mutagenesis
Volume53
Issue number9
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • Aging
  • Cancer
  • DNA polymerase
  • Mouse models

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

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