Mouse models of diabetic neuropathy

Kelli A. Sullivan, John M. Hayes, Timothy D. Wiggin, Carey Backus, Sang Su Oh, Stephen I. Lentz, Frank Brosius, Eva L. Feldman

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

Diabetic neuropathy (DN) is a debilitating complication of type 1 and type 2 diabetes. Rodent models of DN do not fully replicate the pathology observed in human patients. We examined DN in streptozotocin (STZ)-induced [B6] and spontaneous type 1 diabetes [B6Ins2Akita] and spontaneous type 2 diabetes [B6-db/db, BKS-db/db]. Despite persistent hyperglycemia, the STZ-treated B6 and B6Ins2Akita mice were resistant to the development of DN. In contrast, DN developed in both type 2 diabetes models: the B6-db/db and BKS-db/db mice. The persistence of hyperglycemia and development of DN in the B6-db/db mice required an increased fat diet while the BKS-db/db mice developed severe DN and remained hyperglycemic on standard mouse chow. Our data support the hypothesis that genetic background and diet influence the development of DN and should be considered when developing new models of DN.

Original languageEnglish (US)
Pages (from-to)276-285
Number of pages10
JournalNeurobiology of Disease
Volume28
Issue number3
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • B6Ins2
  • BKS
  • Dorsal root ganglia
  • Sciatic nerve
  • Streptozotocin

ASJC Scopus subject areas

  • Neurology

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