Mouse models of diabetic nephropathy

Matthew D. Breyer; Erwin Böttinger; Frank C. Brosius; Thomas M. Coffman; Raymond C. Harris; Charles W. Heilig; Kumar Sharma

doi:10.1681/ASN.2004080648

Mouse models of diabetic nephropathy

Matthew D. Breyer, Erwin Böttinger, Frank C. Brosius, Thomas M. Coffman, Raymond C. Harris, Charles W. Heilig, Kumar Sharma

Research output: Contribution to journal › Review article › peer-review

482 Scopus citations

Abstract

Mice provide an experimental model of unparalleled flexibility for studying mammalian diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal complications of diabetes. Much remains to be established regarding the course of diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are most susceptible to renal injury from diabetes. Through the use of the unique genetic reagents available in mice (including knockouts and transgenics), the validation of a mouse model reproducing human DN should significantly facilitate the understanding of the underlying genetic mechanisms that contribute to the development of DN. Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans.

Original language	English (US)
Pages (from-to)	27-45
Number of pages	19
Journal	Journal of the American Society of Nephrology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1681/ASN.2004080648
State	Published - 2005
Externally published	Yes

ASJC Scopus subject areas

Nephrology

Access to Document

10.1681/ASN.2004080648

Cite this

@article{d80a42c8f9254a689828c1617b8faad3,

title = "Mouse models of diabetic nephropathy",

abstract = "Mice provide an experimental model of unparalleled flexibility for studying mammalian diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal complications of diabetes. Much remains to be established regarding the course of diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are most susceptible to renal injury from diabetes. Through the use of the unique genetic reagents available in mice (including knockouts and transgenics), the validation of a mouse model reproducing human DN should significantly facilitate the understanding of the underlying genetic mechanisms that contribute to the development of DN. Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans.",

author = "Breyer, {Matthew D.} and Erwin B{\"o}ttinger and Brosius, {Frank C.} and Coffman, {Thomas M.} and Harris, {Raymond C.} and Heilig, {Charles W.} and Kumar Sharma",

year = "2005",

doi = "10.1681/ASN.2004080648",

language = "English (US)",

volume = "16",

pages = "27--45",

journal = "Journal of the American Society of Nephrology",

issn = "1046-6673",

publisher = "Wolters Kluwer Health",

number = "1",

}

TY - JOUR

T1 - Mouse models of diabetic nephropathy

AU - Breyer, Matthew D.

AU - Böttinger, Erwin

AU - Brosius, Frank C.

AU - Coffman, Thomas M.

AU - Harris, Raymond C.

AU - Heilig, Charles W.

AU - Sharma, Kumar

PY - 2005

Y1 - 2005

N2 - Mice provide an experimental model of unparalleled flexibility for studying mammalian diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal complications of diabetes. Much remains to be established regarding the course of diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are most susceptible to renal injury from diabetes. Through the use of the unique genetic reagents available in mice (including knockouts and transgenics), the validation of a mouse model reproducing human DN should significantly facilitate the understanding of the underlying genetic mechanisms that contribute to the development of DN. Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans.

AB - Mice provide an experimental model of unparalleled flexibility for studying mammalian diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal complications of diabetes. Much remains to be established regarding the course of diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are most susceptible to renal injury from diabetes. Through the use of the unique genetic reagents available in mice (including knockouts and transgenics), the validation of a mouse model reproducing human DN should significantly facilitate the understanding of the underlying genetic mechanisms that contribute to the development of DN. Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans.

UR - http://www.scopus.com/inward/record.url?scp=21644463370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21644463370&partnerID=8YFLogxK

U2 - 10.1681/ASN.2004080648

DO - 10.1681/ASN.2004080648

M3 - Review article

C2 - 15563560

AN - SCOPUS:21644463370

SN - 1046-6673

VL - 16

SP - 27

EP - 45

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

IS - 1

ER -

Mouse models of diabetic nephropathy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this