TY - JOUR
T1 - Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection
AU - Woods, J. P.
AU - Frelinger, J. A.
AU - Warrack, G.
AU - Cannon, J. G.
PY - 1988
Y1 - 1988
N2 - We surveyed a number of inbred mouse strains for susceptibility to meningococcemia. Mice of all strains became bacteremic after intraperitoneal injection of a serogroup C, serotype 2a human disease isolate, but the strains differed in levels of bacteremia, indicating influences of the host genome on susceptibility. There was no significant correlation between level of bacteremia and differences at major histocompatibility or immunoglobulin loci; the Salmonella susceptibility locus, Ity; the complement C5 locus, Hc; the antibody response locus, xid; or the transferrin locus, Trf. However, the Lps locus, which influences a range of host cellular responses to endotoxin and affects susceptibility to Salmonella typhimurium, did influence susceptibility to meningococcemia. There were significant differences in levels of bacteremia between C3H/HeJ (Lps(d)) mice and each of the other strains (all Lps(n)). We confirmed the association of the Lps(d) genotype with susceptibility by using coisogenic strains from two widely separated mouse lineages: C3H and B10. Lps(d) mice experienced a 1,000-fold proliferation of bacteria and were bacteremic for days before clearing the infection. In contrast, Lps(n) mice cleared the bacteremia in less than 1 day. There was no difference in meningococcal growth in vitro in serum from C3H/HeJ and coisogenic C3H/HeN (Lps(n)) mice, suggesting that the Lps-related difference in susceptibility may involve a cellular response.
AB - We surveyed a number of inbred mouse strains for susceptibility to meningococcemia. Mice of all strains became bacteremic after intraperitoneal injection of a serogroup C, serotype 2a human disease isolate, but the strains differed in levels of bacteremia, indicating influences of the host genome on susceptibility. There was no significant correlation between level of bacteremia and differences at major histocompatibility or immunoglobulin loci; the Salmonella susceptibility locus, Ity; the complement C5 locus, Hc; the antibody response locus, xid; or the transferrin locus, Trf. However, the Lps locus, which influences a range of host cellular responses to endotoxin and affects susceptibility to Salmonella typhimurium, did influence susceptibility to meningococcemia. There were significant differences in levels of bacteremia between C3H/HeJ (Lps(d)) mice and each of the other strains (all Lps(n)). We confirmed the association of the Lps(d) genotype with susceptibility by using coisogenic strains from two widely separated mouse lineages: C3H and B10. Lps(d) mice experienced a 1,000-fold proliferation of bacteria and were bacteremic for days before clearing the infection. In contrast, Lps(n) mice cleared the bacteremia in less than 1 day. There was no difference in meningococcal growth in vitro in serum from C3H/HeJ and coisogenic C3H/HeN (Lps(n)) mice, suggesting that the Lps-related difference in susceptibility may involve a cellular response.
UR - http://www.scopus.com/inward/record.url?scp=0023690962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023690962&partnerID=8YFLogxK
U2 - 10.1128/iai.56.8.1950-1955.1988
DO - 10.1128/iai.56.8.1950-1955.1988
M3 - Article
C2 - 3397181
AN - SCOPUS:0023690962
SN - 0019-9567
VL - 56
SP - 1950
EP - 1955
JO - Infection and Immunity
JF - Infection and Immunity
IS - 8
ER -