Motility effects of opioid peptides in dog intestine

Thomas F. Burks; Lane D. Hirning; James J. Galligan; Thomas P. Davis

doi:10.1016/0024-3205(82)90127-8

Motility effects of opioid peptides in dog intestine

Thomas F. Burks, Lane D. Hirning, James J. Galligan, Thomas P. Davis

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Six opioid peptides, like morphine, were found to produce dose-dependent contractions of dog isolated intestine when administered as intraarterial boluses. The increases in incidence and amplitude of intestinal contractions were antagonized by naloxone. The rank order of potency of the opioid agonists tested was D-Ala²-met-enkephalinamide > D-Ala²-leu-enkephalinamide > met-enkephalin > β-endorphin 1-31 > morphine ≥ morphiceptin > dynorphin 1-13. The contractions induced by two opioid agonists displayed differential sensitivity to blockade by tetrodotoxin (TTX). Met-enkephalin was barely affected by concentrations of TTX that markedly reduced responses to morphiceptin. Some portion of the motility effect of met-enkephalin may be exerted directly on intestinal smooth muscle.

Original language	English (US)
Pages (from-to)	2237-2240
Number of pages	4
Journal	Life Sciences
Volume	31
Issue number	20-21
DOIs	https://doi.org/10.1016/0024-3205(82)90127-8
State	Published - 1982

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(82)90127-8

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@article{9f466e74a38c43b6a27f773ebf9d36d3,

title = "Motility effects of opioid peptides in dog intestine",

abstract = "Six opioid peptides, like morphine, were found to produce dose-dependent contractions of dog isolated intestine when administered as intraarterial boluses. The increases in incidence and amplitude of intestinal contractions were antagonized by naloxone. The rank order of potency of the opioid agonists tested was D-Ala2-met-enkephalinamide > D-Ala2-leu-enkephalinamide > met-enkephalin > β-endorphin 1-31 > morphine ≥ morphiceptin > dynorphin 1-13. The contractions induced by two opioid agonists displayed differential sensitivity to blockade by tetrodotoxin (TTX). Met-enkephalin was barely affected by concentrations of TTX that markedly reduced responses to morphiceptin. Some portion of the motility effect of met-enkephalin may be exerted directly on intestinal smooth muscle.",

author = "Burks, {Thomas F.} and Hirning, {Lane D.} and Galligan, {James J.} and Davis, {Thomas P.}",

note = "Funding Information: Naloxone HCl was a generous gift from Endo Laboratories. This work was supported by USPHS Grant Number DA-02163 from NIDA and a grant from the PMA Foundation.",

year = "1982",

doi = "10.1016/0024-3205(82)90127-8",

language = "English (US)",

volume = "31",

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journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Motility effects of opioid peptides in dog intestine

AU - Burks, Thomas F.

AU - Hirning, Lane D.

AU - Galligan, James J.

AU - Davis, Thomas P.

N1 - Funding Information: Naloxone HCl was a generous gift from Endo Laboratories. This work was supported by USPHS Grant Number DA-02163 from NIDA and a grant from the PMA Foundation.

PY - 1982

Y1 - 1982

N2 - Six opioid peptides, like morphine, were found to produce dose-dependent contractions of dog isolated intestine when administered as intraarterial boluses. The increases in incidence and amplitude of intestinal contractions were antagonized by naloxone. The rank order of potency of the opioid agonists tested was D-Ala2-met-enkephalinamide > D-Ala2-leu-enkephalinamide > met-enkephalin > β-endorphin 1-31 > morphine ≥ morphiceptin > dynorphin 1-13. The contractions induced by two opioid agonists displayed differential sensitivity to blockade by tetrodotoxin (TTX). Met-enkephalin was barely affected by concentrations of TTX that markedly reduced responses to morphiceptin. Some portion of the motility effect of met-enkephalin may be exerted directly on intestinal smooth muscle.

AB - Six opioid peptides, like morphine, were found to produce dose-dependent contractions of dog isolated intestine when administered as intraarterial boluses. The increases in incidence and amplitude of intestinal contractions were antagonized by naloxone. The rank order of potency of the opioid agonists tested was D-Ala2-met-enkephalinamide > D-Ala2-leu-enkephalinamide > met-enkephalin > β-endorphin 1-31 > morphine ≥ morphiceptin > dynorphin 1-13. The contractions induced by two opioid agonists displayed differential sensitivity to blockade by tetrodotoxin (TTX). Met-enkephalin was barely affected by concentrations of TTX that markedly reduced responses to morphiceptin. Some portion of the motility effect of met-enkephalin may be exerted directly on intestinal smooth muscle.

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DO - 10.1016/0024-3205(82)90127-8

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VL - 31

SP - 2237

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JO - Life Sciences

JF - Life Sciences

IS - 20-21

ER -

Motility effects of opioid peptides in dog intestine

Abstract

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