Morphological changes in the middle latency response using maximum length sequence stimuli

Stephanie Nagle, Frank E. Musiek

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: The middle latency response (MLR) can be a powerful tool for assessing integrity of cortical and subcortical auditory structures. Most research on the MLR, however, is constrained to relatively slow repetition rates by the time window necessary for response acquisition. Maximum length sequence (MLS) paradigms enable the recording of the MLR at high repetition rates, which could reduce test time and provide information about the behavior of auditory structures at rapid rates of stimulation. Purposes: To examine potential timing advantages and differences in waveforms between an MLS-MLR paradigm compared to a conventional MLR paradigm (Experiment 1), and to examine effects of rate on MLR morphology within the MLS paradigm (Experiment 2). Research Design: A repeated measures study. All subjects within each experiment underwent every condition for that experiment. Study Sample: Ten young adult female subjects participated in each experiment of this study. All subjects had normal hearing and negative neurological history. Data Collection and Analysis: Latency and amplitude values as well as the presence/absence of Na, Pa, Nb, and Pb components of the MLR were measured. Comparisons were made between the MLS-MLR and conventional MLR paradigms, as well as between repetition rates within the MLS-MLR paradigm. Results: Significant latency and amplitude differences were found between MLS and conventional MLR paradigms. The late components of the MLR (Nb, Pb) were present significantly more often when the MLS paradigm was used. No timing advantage was found with the MLS-MLR paradigm. Within the MLS paradigm, as repetition rate increases, latency becomes significantly shorter and amplitude significantly lower. Conclusions: Middle latency responses evoked by the MLS-MLR paradigm show significant differences from those evoked by a conventional MLR paradigm. The MLS-MLR paradigm can reliably evoke the late components (Nb, Pb) of the MLR and may be an important clinical tool for future investigation of these elements.

Original languageEnglish (US)
Pages (from-to)492-502
Number of pages11
JournalJournal of the American Academy of Audiology
Issue number8
StatePublished - Sep 2009
Externally publishedYes


  • Auditory evoked potentials
  • Central auditory processing
  • Repetition rate

ASJC Scopus subject areas

  • Speech and Hearing


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