Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

Edita Navratilova, Miriam C. Eaton, Dagmar Stropova, Eva V. Varga, Todd W. Vanderah, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S363 may contribute to δ-opioid receptor desensitization by morphine.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - Sep 20 2005


  • Morphine
  • Receptor phosphorylation
  • δ-opioid receptor

ASJC Scopus subject areas

  • Pharmacology


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