Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

Edita Navratilova; Miriam C. Eaton; Dagmar Stropova; Eva V. Varga; Todd W. Vanderah; William R. Roeske; Henry I. Yamamura

doi:10.1016/j.ejphar.2005.07.024

Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

Edita Navratilova, Miriam C. Eaton, Dagmar Stropova, Eva V. Varga, Todd W. Vanderah, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S³⁶³ in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S³⁶³ may contribute to δ-opioid receptor desensitization by morphine.

Original language	English (US)
Pages (from-to)	212-214
Number of pages	3
Journal	European Journal of Pharmacology
Volume	519
Issue number	3
DOIs	https://doi.org/10.1016/j.ejphar.2005.07.024
State	Published - Sep 20 2005

Keywords

Morphine
Receptor phosphorylation
δ-opioid receptor

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2005.07.024

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title = "Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363",

abstract = "After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S363 may contribute to δ-opioid receptor desensitization by morphine.",

keywords = "Morphine, Receptor phosphorylation, δ-opioid receptor",

author = "Edita Navratilova and Eaton, {Miriam C.} and Dagmar Stropova and Varga, {Eva V.} and Vanderah, {Todd W.} and Roeske, {William R.} and Yamamura, {Henry I.}",

note = "Funding Information: The authors thank Michelle Thatcher and Carol Haussler for maintaining the cell cultures. This work was supported by grants from the National Institutes of Health.",

year = "2005",

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doi = "10.1016/j.ejphar.2005.07.024",

language = "English (US)",

volume = "519",

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TY - JOUR

T1 - Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

AU - Navratilova, Edita

AU - Eaton, Miriam C.

AU - Stropova, Dagmar

AU - Varga, Eva V.

AU - Vanderah, Todd W.

AU - Roeske, William R.

AU - Yamamura, Henry I.

N1 - Funding Information: The authors thank Michelle Thatcher and Carol Haussler for maintaining the cell cultures. This work was supported by grants from the National Institutes of Health.

PY - 2005/9/20

Y1 - 2005/9/20

N2 - After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S363 may contribute to δ-opioid receptor desensitization by morphine.

AB - After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S363 may contribute to δ-opioid receptor desensitization by morphine.

KW - Morphine

KW - Receptor phosphorylation

KW - δ-opioid receptor

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DO - 10.1016/j.ejphar.2005.07.024

M3 - Article

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AN - SCOPUS:24644459306

SN - 0014-2999

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EP - 214

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

Abstract

Keywords

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