TY - JOUR
T1 - Molecular Regulation of Cardiac Chamber-Specific Gene Expression
AU - Small, Eric M.
AU - Krieg, Paul A.
N1 - Funding Information:
The authors thank Benoit Bruneau for critical comments on the manuscript and for providing information prior to publication. P.A.K. is the Allan C. Hudson and Helen Lovaas Endowed Professor of the Sarver Heart Center at the University of Arizona College of Medicine. This work was supported by the Sarver Heart Center and by the National Heart, Lung, and Blood Institute of the National Institutes of Health, grant #HL63926.
PY - 2004/1
Y1 - 2004/1
N2 - This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.
AB - This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.
UR - https://www.scopus.com/pages/publications/0346056964
UR - https://www.scopus.com/pages/publications/0346056964#tab=citedBy
U2 - 10.1016/j.tcm.2003.09.005
DO - 10.1016/j.tcm.2003.09.005
M3 - Review article
C2 - 14720469
AN - SCOPUS:0346056964
SN - 1050-1738
VL - 14
SP - 13
EP - 18
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 1
ER -