Molecular Regulation of Cardiac Chamber-Specific Gene Expression

Eric M. Small; Paul A. Krieg

doi:10.1016/j.tcm.2003.09.005

Molecular Regulation of Cardiac Chamber-Specific Gene Expression

Eric M. Small, Paul A. Krieg

Cellular and Molecular Medicine

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Trends in Cardiovascular Medicine
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.tcm.2003.09.005
State	Published - Jan 2004

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.tcm.2003.09.005

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title = "Molecular Regulation of Cardiac Chamber-Specific Gene Expression",

abstract = "This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.",

author = "Small, {Eric M.} and Krieg, {Paul A.}",

note = "Funding Information: The authors thank Benoit Bruneau for critical comments on the manuscript and for providing information prior to publication. P.A.K. is the Allan C. Hudson and Helen Lovaas Endowed Professor of the Sarver Heart Center at the University of Arizona College of Medicine. This work was supported by the Sarver Heart Center and by the National Heart, Lung, and Blood Institute of the National Institutes of Health, grant #HL63926.",

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Molecular Regulation of Cardiac Chamber-Specific Gene Expression

Abstract

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