Molecular pharmacology of muscarinic receptor heterogeneity

Lin Mei; William R. Roeske; Henry I. Yamamura

doi:10.1016/0024-3205(89)90537-7

Molecular pharmacology of muscarinic receptor heterogeneity

Lin Mei, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journal › Short survey › peer-review

107 Scopus citations

Abstract

Muscarinic receptors can be pharmacologically classified into 3 types at the present time, however, five genes for the receptor have been identified. The muscarinic receptor types have unique antagonist selectivity, distribution and are linked to specific second messenger systems. The interaction between the muscarinic receptor types and G proteins may depend on the systems in which the receptors are integrated. Expression of the cloned gene in mammalian cells will be useful in delineating the relationships between the pharmacological types of muscarinic receptors and their genes and studying the interactions between the receptor, G proteins, and second messenger coupling.

Original language	English (US)
Pages (from-to)	1831-1851
Number of pages	21
Journal	Life Sciences
Volume	45
Issue number	20
DOIs	https://doi.org/10.1016/0024-3205(89)90537-7
State	Published - 1989

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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AB - Muscarinic receptors can be pharmacologically classified into 3 types at the present time, however, five genes for the receptor have been identified. The muscarinic receptor types have unique antagonist selectivity, distribution and are linked to specific second messenger systems. The interaction between the muscarinic receptor types and G proteins may depend on the systems in which the receptors are integrated. Expression of the cloned gene in mammalian cells will be useful in delineating the relationships between the pharmacological types of muscarinic receptors and their genes and studying the interactions between the receptor, G proteins, and second messenger coupling.

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Molecular pharmacology of muscarinic receptor heterogeneity

Abstract

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