Molecular diagnosis of Burkitt's lymphoma

Sandeep S. Dave; Kai Fu; George W. Wright; Lloyd T. Lam; Philip Kluin; Evert Jan Boerma; Timothy C. Greiner; Dennis D. Weisenburger; Andreas Rosenwald; German Ott; Hans Konrad Müller-Hermelink; Randy D. Gascoyne; Jan Delabie; Lisa M. Rimsza; Rita M. Braziel; Thomas M. Grogan; Elias Campo; Elaine S. Jaffe; Bhavana J. Dave; Warren Sanger; Martin Bast; Julie M. Vose; James O. Armitage; Joseph M. Connors; Erlend B. Smeland; Stein Kvaloy; Harald Holte; Richard I. Fisher; Thomas P. Miller; Emilio Montserrat; Wyndham H. Wilson; Manisha Bahl; Hong Zhao; Liming Yang; John Powell; Richard Simon; Wing C. Chan; Louis M. Staudt

doi:10.1056/NEJMoa055759

Molecular diagnosis of Burkitt's lymphoma

Sandeep S. Dave, Kai Fu, George W. Wright, Lloyd T. Lam, Philip Kluin, Evert Jan Boerma, Timothy C. Greiner, Dennis D. Weisenburger, Andreas Rosenwald, German Ott, Hans Konrad Müller-Hermelink, Randy D. Gascoyne, Jan Delabie, Lisa M. Rimsza, Rita M. Braziel, Thomas M. Grogan, Elias Campo, Elaine S. Jaffe, Bhavana J. Dave, Warren SangerMartin Bast, Julie M. Vose, James O. Armitage, Joseph M. Connors, Erlend B. Smeland, Stein Kvaloy, Harald Holte, Richard I. Fisher, Thomas P. Miller, Emilio Montserrat, Wyndham H. Wilson, Manisha Bahl, Hong Zhao, Liming Yang, John Powell, Richard Simon, Wing C. Chan, Louis M. Staudt

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Abstract

BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.

Original language	English (US)
Pages (from-to)	2431-2442
Number of pages	12
Journal	New England Journal of Medicine
Volume	354
Issue number	23
DOIs	https://doi.org/10.1056/NEJMoa055759
State	Published - Jun 8 2006

ASJC Scopus subject areas

General Medicine

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Dave, S. S., Fu, K., Wright, G. W., Lam, L. T., Kluin, P., Boerma, E. J., Greiner, T. C., Weisenburger, D. D., Rosenwald, A., Ott, G., Müller-Hermelink, H. K., Gascoyne, R. D., Delabie, J., Rimsza, L. M., Braziel, R. M., Grogan, T. M., Campo, E., Jaffe, E. S., Dave, B. J., ... Staudt, L. M. (2006). Molecular diagnosis of Burkitt's lymphoma. New England Journal of Medicine, 354(23), 2431-2442. https://doi.org/10.1056/NEJMoa055759

Dave, SS, Fu, K, Wright, GW, Lam, LT, Kluin, P, Boerma, EJ, Greiner, TC, Weisenburger, DD, Rosenwald, A, Ott, G, Müller-Hermelink, HK, Gascoyne, RD, Delabie, J, Rimsza, LM, Braziel, RM, Grogan, TM, Campo, E, Jaffe, ES, Dave, BJ, Sanger, W, Bast, M, Vose, JM, Armitage, JO, Connors, JM, Smeland, EB, Kvaloy, S, Holte, H, Fisher, RI, Miller, TP, Montserrat, E, Wilson, WH, Bahl, M, Zhao, H, Yang, L, Powell, J, Simon, R, Chan, WC & Staudt, LM 2006, 'Molecular diagnosis of Burkitt's lymphoma', New England Journal of Medicine, vol. 354, no. 23, pp. 2431-2442. https://doi.org/10.1056/NEJMoa055759

@article{b3bb55c5ec734407bb2b4a798a59a598,

title = "Molecular diagnosis of Burkitt's lymphoma",

abstract = "BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.",

author = "Dave, {Sandeep S.} and Kai Fu and Wright, {George W.} and Lam, {Lloyd T.} and Philip Kluin and Boerma, {Evert Jan} and Greiner, {Timothy C.} and Weisenburger, {Dennis D.} and Andreas Rosenwald and German Ott and M{\"u}ller-Hermelink, {Hans Konrad} and Gascoyne, {Randy D.} and Jan Delabie and Rimsza, {Lisa M.} and Braziel, {Rita M.} and Grogan, {Thomas M.} and Elias Campo and Jaffe, {Elaine S.} and Dave, {Bhavana J.} and Warren Sanger and Martin Bast and Vose, {Julie M.} and Armitage, {James O.} and Connors, {Joseph M.} and Smeland, {Erlend B.} and Stein Kvaloy and Harald Holte and Fisher, {Richard I.} and Miller, {Thomas P.} and Emilio Montserrat and Wilson, {Wyndham H.} and Manisha Bahl and Hong Zhao and Liming Yang and John Powell and Richard Simon and Chan, {Wing C.} and Staudt, {Louis M.}",

year = "2006",

month = jun,

day = "8",

doi = "10.1056/NEJMoa055759",

language = "English (US)",

volume = "354",

pages = "2431--2442",

journal = "New England Journal of Medicine",

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number = "23",

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TY - JOUR

T1 - Molecular diagnosis of Burkitt's lymphoma

AU - Dave, Sandeep S.

AU - Fu, Kai

AU - Wright, George W.

AU - Lam, Lloyd T.

AU - Kluin, Philip

AU - Boerma, Evert Jan

AU - Greiner, Timothy C.

AU - Weisenburger, Dennis D.

AU - Rosenwald, Andreas

AU - Ott, German

AU - Müller-Hermelink, Hans Konrad

AU - Gascoyne, Randy D.

AU - Delabie, Jan

AU - Rimsza, Lisa M.

AU - Braziel, Rita M.

AU - Grogan, Thomas M.

AU - Campo, Elias

AU - Jaffe, Elaine S.

AU - Dave, Bhavana J.

AU - Sanger, Warren

AU - Bast, Martin

AU - Vose, Julie M.

AU - Armitage, James O.

AU - Connors, Joseph M.

AU - Smeland, Erlend B.

AU - Kvaloy, Stein

AU - Holte, Harald

AU - Fisher, Richard I.

AU - Miller, Thomas P.

AU - Montserrat, Emilio

AU - Wilson, Wyndham H.

AU - Bahl, Manisha

AU - Zhao, Hong

AU - Yang, Liming

AU - Powell, John

AU - Simon, Richard

AU - Chan, Wing C.

AU - Staudt, Louis M.

PY - 2006/6/8

Y1 - 2006/6/8

N2 - BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.

AB - BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.

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U2 - 10.1056/NEJMoa055759

DO - 10.1056/NEJMoa055759

M3 - Article

C2 - 16760443

AN - SCOPUS:33645279862

SN - 0028-4793

VL - 354

SP - 2431

EP - 2442

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 23

ER -

Molecular diagnosis of Burkitt's lymphoma

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