Abstract
We report the novel cloning of the murine PHEX promoter, the gene that is mutated in X-linked hypophosphatemic rickets (XLH). Four promoter/reporter gene constructs, -133/+104, -542/+104, -1061/+104, and -2866/+104, showed significant luciferase activity (4.9-13.2-fold over background) when transfected into rat osteogenic sarcoma (UMR-106) cells.
Original language | English (US) |
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Pages (from-to) | 333-336 |
Number of pages | 4 |
Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
Volume | 1493 |
Issue number | 3 |
DOIs | |
State | Published - Oct 2 2000 |
Keywords
- Hyp mouse
- PEX
- UMR-106 cells
- X-linked rickets
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Genetics