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Molecular Basis for Sequence-Specific DNA Alkylation by CC-1065
Laurence H. Hurley
, Chong soon Lee
, J. Patrick Mcgovren
, Martha A. Warpehoski
, Mark A. Mitchell
, Robert C. Kelly
, Paul A. Aristoff
Research output
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Contribution to journal
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Article
›
peer-review
189
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Keyphrases
Sequence-specific DNA
100%
DNA Alkylation
100%
CC-1065
100%
Alkylation
75%
Sequence Specificity
62%
Noncovalent Interactions
37%
Minor Groove
37%
β Subunit
25%
Local DNA Structures
25%
Asymmetric Effects
25%
Adduct Formation
25%
Biological Potency
25%
Covalent Bond Formation
25%
Non-reactivity
25%
Sequence-dependent
25%
C Subunit
25%
Indirect Evidence
12%
Trimeric
12%
Site Reaction
12%
Modified Bases
12%
Footprinting
12%
Analog Series
12%
Non-covalent
12%
DNA Structures
12%
Apparent Rate Constant
12%
DNA Conformation
12%
Conformational Change
12%
Pyrroloindole
12%
Linear DNA
12%
Indole
12%
Covalent Adduct
12%
Synthetic Analogues
12%
Cyclopropanols
12%
Antitumor Antibiotic
12%
DNA Fragments
12%
Groove Interaction
12%
Chemistry
Deoxyribonucleic Acid
100%
DNA Alkylation
100%
Adenine
55%
DNA Structure
33%
Covalent Bond
22%
Alkylation
22%
Pair-Base
11%
Binding Site
11%
Pyrroloindole
11%
Antineoplastic Antibiotic
11%
Base
11%
Indole
11%
Biochemistry, Genetics and Molecular Biology
Adenine
100%
DNA Alkylation
100%
Covalent Bond
40%
Alkylation
40%
Conformational Change
20%
DNA Conformation
20%
Pharmacology, Toxicology and Pharmaceutical Science
Adenine
100%
Covalent Bond
40%
DNA Fragment
20%
Antineoplastic Antibiotic
20%
Indole
20%