Abstract
In this article we first very briefly review current approaches to the design of drugs that have specificity for the modulation of gene expression and selectivity for target cells at the transcription level by targeting DNA. We focus this review on our approaches to gaining selectivity by drug-induced architectural alteration in DNA structure, selectivity achieved by protein-induced changes in DNA structure or dynamics, and hijacking of nuclear receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Anti-Cancer Drug Design |
| Volume | 14 |
| Issue number | 1 |
| State | Published - Feb 1999 |
| Externally published | Yes |
Keywords
- Antitumour drugs
- DNA bending
- Protein-DNA complexes
- Transcriptional control
ASJC Scopus subject areas
- Biochemistry
- Oncology
- General Biochemistry, Genetics and Molecular Biology
- Pharmacology
- Drug Discovery
- Organic Chemistry