Abstract
ABSTRACT: In vitro pretreatment of peripheral blood leukocytes (PBL) from patients with prostatic cancer with therapeutically significant levels of diethylstilbestrol diphosphate (DES‐P) has been shown to suppress cell‐mediated tumor‐associated immunity (TAI). In the present retrospective evaluation of TAI in 27 patients with prostatic cancer, prior to and following the receipt of nonhormonal and hormonal, ie, estrogen and/or orchiectomy, therapy, patients receiving hormonal therapy possessed significantly (p < 0.05) lower levels of TAI, irrespective of the in vitro pretreatment of their PBL with DES‐P. Suppression of TAI by in vitro pretreatment of PBL with DES‐P and in prostatic cancer patients receiving estrogen therapy parallels and extends earlier observations of the estrogenic suppression of nonspecific, mitogen‐induced cellular responsiveness. The clinical relevancy of the immunosuppressive effects of hormonal therapy on tumor‐host responsiveness is considered in view of the present and previous studies. 1981 Munksgaard
| Original language | English (US) |
|---|---|
| Pages (from-to) | 206-209 |
| Number of pages | 4 |
| Journal | American Journal of Reproductive Immunology |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1981 |
| Externally published | Yes |
Keywords
- Cell‐mediated immunity
- hormonal therapy
- immunosuppression
- leukocyte adherence inhibition
- nonhormonal therapy
- tumor‐associated immunity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Reproductive Medicine
- Obstetrics and Gynecology