TY - JOUR
T1 - Modulation of release of paclitaxel from composite cerasomes
AU - Cao, Zhong
AU - Yue, Xiuli
AU - Jin, Yushen
AU - Wu, Xiaoyi
AU - Dai, Zhifei
N1 - Funding Information:
This research was financially supported by National Natural Science Foundation of China ( NSFC-30970829 and 20977021 ).
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Efforts to improve the stability of liposomes have recently led to the development of organic-inorganic liposomal cerasomes. In this study, we explore the potential to modulate the sustained release of paclitaxel from cerasomes by alteration in vesicle composition. Specifically, composite cerasomes have been prepared from mixtures of cerasome-forming lipid (lipid 1) and 1,2-distearoyl- sn-glycero-3-phosphocholine (lipid 2) via one-step construction. The influences of vesicle composition on the physical properties (e.g., particle diameter and surface charge density), physiochemical and long-term storage stability, drug-loading capacity, and release rates of paclitaxel have been investigated. Notably, a wide range of the release profiles of paclitaxel have been achieved by varying the contents of lipid 2, and the composite vesicles display excellent stability when the percentage content of lipid 2 is lower than 50%. Composite vesicles composed of lipids 1 and 2 at a 1:1 molar ratio also exhibited good cytocompatibility and the released paclitaxel effectively inhibit the proliferation of HeLa cancer cells. Together, the development of composite vesicles offers a promising strategy to obtain excellent stability, good drug-loading capacity and cytocompatibility, and enhanced paclitaxel release in single vesicles.
AB - Efforts to improve the stability of liposomes have recently led to the development of organic-inorganic liposomal cerasomes. In this study, we explore the potential to modulate the sustained release of paclitaxel from cerasomes by alteration in vesicle composition. Specifically, composite cerasomes have been prepared from mixtures of cerasome-forming lipid (lipid 1) and 1,2-distearoyl- sn-glycero-3-phosphocholine (lipid 2) via one-step construction. The influences of vesicle composition on the physical properties (e.g., particle diameter and surface charge density), physiochemical and long-term storage stability, drug-loading capacity, and release rates of paclitaxel have been investigated. Notably, a wide range of the release profiles of paclitaxel have been achieved by varying the contents of lipid 2, and the composite vesicles display excellent stability when the percentage content of lipid 2 is lower than 50%. Composite vesicles composed of lipids 1 and 2 at a 1:1 molar ratio also exhibited good cytocompatibility and the released paclitaxel effectively inhibit the proliferation of HeLa cancer cells. Together, the development of composite vesicles offers a promising strategy to obtain excellent stability, good drug-loading capacity and cytocompatibility, and enhanced paclitaxel release in single vesicles.
KW - Composite cerasomes
KW - Controlled drug release
KW - Paclitaxel
KW - Stability
KW - Vesicle composition
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U2 - 10.1016/j.colsurfb.2012.05.001
DO - 10.1016/j.colsurfb.2012.05.001
M3 - Article
C2 - 22659210
AN - SCOPUS:84861537435
SN - 0927-7765
VL - 98
SP - 97
EP - 104
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -