Modulation of phencyclidine (PCP) pharmacokinetics with PCP-specific fab fragments

S. M. Owens, M. Mayersohn

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A promising technique for detoxification of certain drugs is the use of drug-specific antibody fragments (Fab, the antigen-binding fragment of IgG). This type of treatment has been shown to reverse digoxin and digitoxin toxicity rapidly in both animals and humans. The purpose of this paper is to discuss the important factors in the use of immunotherapy for treating PCP toxicity and to present preliminary data on the effects of anti-PCP Fab fragments on PCP pharmacokinetics in dogs.

Original languageEnglish (US)
Pages (from-to)112-126
Number of pages15
JournalNIDA Research Monograph Series
VolumeNO. 64
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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