Modular Camera Design Study for Human Brain SPECT System

Kimberly J. Doty, Xin Li, R. Garrett Richards, Michael A. King, Phillip H. Kuo, Matthew A. Kupinski, Lars R. Furenlid

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Single-photon emission computed tomography (SPECT) can be used with a wide variety of radioligands for drug discovery and pharmacokinetic studies of promising drugs for neurodegenerative diseases. We are developing a human brain SPECT system with a stationary array of detectors that will provide dynamic high-resolution, high-sensitivity imaging. We are assessing the benefits of incorporating cylindrically curved scintillation detectors, which - due primarily to significant reduction in depth of interaction uncertainty - have resolution advantages over planar detectors at the edges. We are studying the use of a cylindrically curved to planar fiber optic plate to transfer the scintillation light from the curved crystal and light guide to a planar surface for photodetection using conventional methods. Another design component being evaluated is a novel light-sensor configuration combining photomultiplier tubes (PMTs) and silicon photomultipliers (SiPMs). Simulation methods were used to predict performance of a variety of detector layouts. The purpose of the study was to balance the tradeoff between detector cost and performance, as the final imager will be comprised of 24 camera modules. We demonstrate that combining PMTs and SiPMs for electronic readout achieves a spatial resolution advantage at the edges while maintaining a lower cost than a full SiPM readout or a curved detector.

Original languageEnglish (US)
Title of host publication2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728176932
DOIs
StatePublished - 2020
Externally publishedYes
Event2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020 - Boston, United States
Duration: Oct 31 2020Nov 7 2020

Publication series

Name2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020

Conference

Conference2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
Country/TerritoryUnited States
CityBoston
Period10/31/2011/7/20

Keywords

  • Curved gamma camera
  • Fiber optic plate
  • Gamma camera design
  • Human brain imager
  • Molecular imaging
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Signal Processing
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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