Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine

Cristobal L. Miranda; Donald R. Buhler; Howard S. Ramsdell; Peter R. Cheeke; John A. Schmitz

doi:10.1016/0378-4274(82)90071-6

Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine

Cristobal L. Miranda, Donald R. Buhler, Howard S. Ramsdell, Peter R. Cheeke, John A. Schmitz

Arizona Veterinary Diagnostic Laboratory

Research output: Contribution to journal › Article › peer-review

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Abstract

The chronic hepatotoxic effects of mixed pyrrolizidine alkaloids (PAs) from the poisonous plant tansy ragwort (Senecio jacobaea) and the ability of butylated hydroxyanisole (BHA) and cysteine to alter these hepatic effects were studied in male rats. In control animals, the i.p. administration of a single dose of mixed PAs, 160 mg/kg, produced marked fibrosis, biliary hyperplasia, megalocytosis, necrosis and calcification in liver 8 weeks post injection. In contrast, consumption of 0.75% BHA diet 10 days before and 14 days after PA administration reduced the incidence and/or completely prevented the occurrence of these pathological changes. Similar treatment with 1% cysteine, however, only reduced the severity of the hepatic lesions.

Original language	English (US)
Pages (from-to)	177-182
Number of pages	6
Journal	Toxicology letters
Volume	10
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-4274(82)90071-6
State	Published - Feb 1982

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Toxicology

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@article{44675916f6ab465d99a941dbf27a7d5b,

title = "Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine",

abstract = "The chronic hepatotoxic effects of mixed pyrrolizidine alkaloids (PAs) from the poisonous plant tansy ragwort (Senecio jacobaea) and the ability of butylated hydroxyanisole (BHA) and cysteine to alter these hepatic effects were studied in male rats. In control animals, the i.p. administration of a single dose of mixed PAs, 160 mg/kg, produced marked fibrosis, biliary hyperplasia, megalocytosis, necrosis and calcification in liver 8 weeks post injection. In contrast, consumption of 0.75% BHA diet 10 days before and 14 days after PA administration reduced the incidence and/or completely prevented the occurrence of these pathological changes. Similar treatment with 1% cysteine, however, only reduced the severity of the hepatic lesions.",

author = "Miranda, {Cristobal L.} and Buhler, {Donald R.} and Ramsdell, {Howard S.} and Cheeke, {Peter R.} and Schmitz, {John A.}",

note = "Funding Information: The authors thank Charlene Karr-May, Ralph Reed, Shahla Sadri, John Amberg and Julie Rosenkoetter for their technical assistance with this work. This research was supported by grants from the National Institutes of Health Nos. CA-22524 and ES-00210. This manuscript was issued as Oregon Agricultural Experiment Station Technical Paper No. 5855.",

year = "1982",

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doi = "10.1016/0378-4274(82)90071-6",

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volume = "10",

pages = "177--182",

journal = "Toxicology letters",

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T1 - Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine

AU - Miranda, Cristobal L.

AU - Buhler, Donald R.

AU - Ramsdell, Howard S.

AU - Cheeke, Peter R.

AU - Schmitz, John A.

N1 - Funding Information: The authors thank Charlene Karr-May, Ralph Reed, Shahla Sadri, John Amberg and Julie Rosenkoetter for their technical assistance with this work. This research was supported by grants from the National Institutes of Health Nos. CA-22524 and ES-00210. This manuscript was issued as Oregon Agricultural Experiment Station Technical Paper No. 5855.

PY - 1982/2

Y1 - 1982/2

N2 - The chronic hepatotoxic effects of mixed pyrrolizidine alkaloids (PAs) from the poisonous plant tansy ragwort (Senecio jacobaea) and the ability of butylated hydroxyanisole (BHA) and cysteine to alter these hepatic effects were studied in male rats. In control animals, the i.p. administration of a single dose of mixed PAs, 160 mg/kg, produced marked fibrosis, biliary hyperplasia, megalocytosis, necrosis and calcification in liver 8 weeks post injection. In contrast, consumption of 0.75% BHA diet 10 days before and 14 days after PA administration reduced the incidence and/or completely prevented the occurrence of these pathological changes. Similar treatment with 1% cysteine, however, only reduced the severity of the hepatic lesions.

AB - The chronic hepatotoxic effects of mixed pyrrolizidine alkaloids (PAs) from the poisonous plant tansy ragwort (Senecio jacobaea) and the ability of butylated hydroxyanisole (BHA) and cysteine to alter these hepatic effects were studied in male rats. In control animals, the i.p. administration of a single dose of mixed PAs, 160 mg/kg, produced marked fibrosis, biliary hyperplasia, megalocytosis, necrosis and calcification in liver 8 weeks post injection. In contrast, consumption of 0.75% BHA diet 10 days before and 14 days after PA administration reduced the incidence and/or completely prevented the occurrence of these pathological changes. Similar treatment with 1% cysteine, however, only reduced the severity of the hepatic lesions.

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SN - 0378-4274

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JO - Toxicology letters

JF - Toxicology letters

IS - 2-3

ER -

Modifications of chronic hepatotoxicity of pyrrolizidine (Senecio) alkaloids by butylated hydroxyanisole and cysteine

Abstract

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