Models of frequency preferences of prefrontal cortical neurons

Arthur R. Houweling, Rashmi H. Modi, Paul Ganter, Jean Marc Fellous, Terrence J. Sejnowski

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The reliability of spike trains generated by sinusoidal current injections in prefrontal cortical pyramidal cells and interneurons depends strongly on the input frequency. We constructed computational models in order to study how cellular properties affect reliability. The models reproduced the main experimental findings: subthreshold oscillations, resonance and reliability of spike timing. The amplitude of intrinsic noise in the model determined the number of reliable frequency bands. In addition, the frequency content of the noise did not affect reliability.

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
StatePublished - Jun 2001

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence


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