Modeling the sustained release of lipophilic drugs from liposomes

Like Zeng; Xiaoyi Wu

doi:10.1063/1.3479924

Modeling the sustained release of lipophilic drugs from liposomes

Like Zeng
, Xiaoyi Wu

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.

Original language	English (US)
Article number	073701
Journal	Applied Physics Letters
Volume	97
Issue number	7
DOIs	https://doi.org/10.1063/1.3479924
State	Published - Aug 16 2010

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.3479924

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abstract = "The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.",

author = "Like Zeng and Xiaoyi Wu",

note = "Funding Information: This work was supported by the NSF grants (Grant Nos. CMMI-0856215 and CMMI-0855890) and the AHA Beginning Grant-in-Aid under Grant No. 09BGIA2250621.",

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Y1 - 2010/8/16

N2 - The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.

AB - The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.

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Modeling the sustained release of lipophilic drugs from liposomes

Abstract

ASJC Scopus subject areas

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