Modeling fluid percussion injury: Relevance to human traumatic brain injury

Katharine Eakin, Rachel K. Rowe, Jonathan Lifshitz

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations


Fluid percussion injury (FPI) is capable of producing diffuse (midline FPI) and mixed (focal and diffuse; lateral FPI) injury pathologies that are frequently seen following human traumatic brain injury (TBI). The injuries produced with this model are scalable and can produce mild, moderate, and severe injury severities. The surgical procedures and assessment techniques described in this chapter are specific to adult rat and mouse models. However, this injury model can be used with subjects of any age and across different species. By following the procedures detailed in this chapter, it is possible to reproduce behavioral and pathophysiological characteristics of TBI in laboratory animals.

Original languageEnglish (US)
Title of host publicationBrain Neurotrauma
Subtitle of host publicationMolecular, Neuropsychological, and Rehabilitation Aspects
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781466565999
ISBN (Print)9781466565982
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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