Modeling fluid percussion injury: Relevance to human traumatic brain injury

Katharine Eakin; Rachel K. Rowe; Jonathan Lifshitz

doi:10.1201/b18126

Modeling fluid percussion injury: Relevance to human traumatic brain injury

Katharine Eakin, Rachel K. Rowe, Jonathan Lifshitz

Child Health, Phoenix

Research output: Chapter in Book/Report/Conference proceeding › Chapter

18 Scopus citations

Abstract

Fluid percussion injury (FPI) is capable of producing diffuse (midline FPI) and mixed (focal and diffuse; lateral FPI) injury pathologies that are frequently seen following human traumatic brain injury (TBI). The injuries produced with this model are scalable and can produce mild, moderate, and severe injury severities. The surgical procedures and assessment techniques described in this chapter are specific to adult rat and mouse models. However, this injury model can be used with subjects of any age and across different species. By following the procedures detailed in this chapter, it is possible to reproduce behavioral and pathophysiological characteristics of TBI in laboratory animals.

Original language	English (US)
Title of host publication	Brain Neurotrauma
Subtitle of host publication	Molecular, Neuropsychological, and Rehabilitation Aspects
Publisher	CRC Press
Pages	259-272
Number of pages	14
ISBN (Electronic)	9781466565999
ISBN (Print)	9781466565982
DOIs	https://doi.org/10.1201/b18126
State	Published - Jan 1 2015

ASJC Scopus subject areas

Neuroscience(all)
Medicine(all)

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Modeling fluid percussion injury: Relevance to human traumatic brain injury

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