Mobilizing immune cells with exercise for cancer immunotherapy

Richard J. Simpson, Austin B. Bigley, Nadia Agha, Patrick J. Hanley, Catherine M. Bollard

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Hematopoietic stem cell (HSC) transplantation and adoptive transfer immunotherapy are effective in treating blood cancers and posttransplant infections, but low-circulating cell numbers in patients and donors are oftentimes a limiting factor. We postulate that a single exercise bout will increase the yield of patient- and donor-derived HSCs and cytotoxic lymphocytes to improve this form of treatment for cancer patients.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalExercise and Sport Sciences Reviews
Volume45
Issue number3
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

Keywords

  • adoptive transfer
  • exercise immunology
  • hematopoietic stem cell transplantation
  • NK cell
  • T cell
  • tumor antigens
  • viral infections

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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