Mobilizing immune cells with exercise for cancer immunotherapy

Richard J. Simpson; Austin B. Bigley; Nadia Agha; Patrick J. Hanley; Catherine M. Bollard

doi:10.1249/JES.0000000000000114

Mobilizing immune cells with exercise for cancer immunotherapy

Richard J. Simpson, Austin B. Bigley, Nadia Agha, Patrick J. Hanley, Catherine M. Bollard

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Hematopoietic stem cell (HSC) transplantation and adoptive transfer immunotherapy are effective in treating blood cancers and posttransplant infections, but low-circulating cell numbers in patients and donors are oftentimes a limiting factor. We postulate that a single exercise bout will increase the yield of patient- and donor-derived HSCs and cytotoxic lymphocytes to improve this form of treatment for cancer patients.

Original language	English (US)
Pages (from-to)	163-172
Number of pages	10
Journal	Exercise and Sport Sciences Reviews
Volume	45
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000114
State	Published - Jul 1 2017
Externally published	Yes

Keywords

NK cell
T cell
adoptive transfer
exercise immunology
hematopoietic stem cell transplantation
tumor antigens
viral infections

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000114

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abstract = "Hematopoietic stem cell (HSC) transplantation and adoptive transfer immunotherapy are effective in treating blood cancers and posttransplant infections, but low-circulating cell numbers in patients and donors are oftentimes a limiting factor. We postulate that a single exercise bout will increase the yield of patient- and donor-derived HSCs and cytotoxic lymphocytes to improve this form of treatment for cancer patients.",

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AU - Bigley, Austin B.

AU - Agha, Nadia

AU - Hanley, Patrick J.

AU - Bollard, Catherine M.

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AB - Hematopoietic stem cell (HSC) transplantation and adoptive transfer immunotherapy are effective in treating blood cancers and posttransplant infections, but low-circulating cell numbers in patients and donors are oftentimes a limiting factor. We postulate that a single exercise bout will increase the yield of patient- and donor-derived HSCs and cytotoxic lymphocytes to improve this form of treatment for cancer patients.

KW - NK cell

KW - T cell

KW - adoptive transfer

KW - exercise immunology

KW - hematopoietic stem cell transplantation

KW - tumor antigens

KW - viral infections

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Mobilizing immune cells with exercise for cancer immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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