Mitophagy mechanisms and role in human diseases

Matthew Redmann, Matthew Dodson, Michaël Boyer-Guittaut, Victor Darley-Usmar, Jianhua Zhang

Research output: Contribution to journalShort surveypeer-review

94 Scopus citations

Abstract

Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume53
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • Cancer
  • Heart disease
  • Mitochondria
  • Mitophagy
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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