Abstract
Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.
Original language | English (US) |
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Pages (from-to) | 127-133 |
Number of pages | 7 |
Journal | International Journal of Biochemistry and Cell Biology |
Volume | 53 |
DOIs | |
State | Published - Aug 2014 |
Externally published | Yes |
Keywords
- Cancer
- Heart disease
- Mitochondria
- Mitophagy
- Parkinson's disease
ASJC Scopus subject areas
- Biochemistry
- Cell Biology