Mitophagy mechanisms and role in human diseases

Matthew Redmann; Matthew Dodson; Michaël Boyer-Guittaut; Victor Darley-Usmar; Jianhua Zhang

doi:10.1016/j.biocel.2014.05.010

Mitophagy mechanisms and role in human diseases

Matthew Redmann, Matthew Dodson, Michaël Boyer-Guittaut, Victor Darley-Usmar, Jianhua Zhang

Research output: Contribution to journal › Short survey › peer-review

107 Scopus citations

Abstract

Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.

Original language	English (US)
Pages (from-to)	127-133
Number of pages	7
Journal	International Journal of Biochemistry and Cell Biology
Volume	53
DOIs	https://doi.org/10.1016/j.biocel.2014.05.010
State	Published - Aug 2014
Externally published	Yes

Keywords

Cancer
Heart disease
Mitochondria
Mitophagy
Parkinson's disease

ASJC Scopus subject areas

Biochemistry
Cell Biology

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10.1016/j.biocel.2014.05.010

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@article{abe034ea0b78418eb61df7f7afa61b31,

title = "Mitophagy mechanisms and role in human diseases",

abstract = "Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.",

keywords = "Cancer, Heart disease, Mitochondria, Mitophagy, Parkinson's disease",

author = "Matthew Redmann and Matthew Dodson and Micha{\"e}l Boyer-Guittaut and Victor Darley-Usmar and Jianhua Zhang",

note = "Funding Information: This work was supported by NIH R01-NS064090 and a VA merit award (to JZ).",

year = "2014",

month = aug,

doi = "10.1016/j.biocel.2014.05.010",

language = "English (US)",

volume = "53",

pages = "127--133",

journal = "International Journal of Biochemistry and Cell Biology",

issn = "1357-2725",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Mitophagy mechanisms and role in human diseases

AU - Redmann, Matthew

AU - Dodson, Matthew

AU - Boyer-Guittaut, Michaël

AU - Darley-Usmar, Victor

AU - Zhang, Jianhua

N1 - Funding Information: This work was supported by NIH R01-NS064090 and a VA merit award (to JZ).

PY - 2014/8

Y1 - 2014/8

N2 - Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.

AB - Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.

KW - Cancer

KW - Heart disease

KW - Mitochondria

KW - Mitophagy

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=84901768886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901768886&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2014.05.010

DO - 10.1016/j.biocel.2014.05.010

M3 - Short survey

C2 - 24842106

AN - SCOPUS:84901768886

SN - 1357-2725

VL - 53

SP - 127

EP - 133

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

ER -

Mitophagy mechanisms and role in human diseases

Abstract

Keywords

ASJC Scopus subject areas

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