Mitochondrial defects in cancer

Jennifer S. Carew, Peng Huang

Research output: Contribution to journalReview articlepeer-review

520 Scopus citations

Abstract

Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications.

Original languageEnglish (US)
Article number9
JournalMolecular Cancer
Volume1
DOIs
StatePublished - Dec 9 2002
Externally publishedYes

Keywords

  • Cancer
  • Free radical
  • Mitochondria
  • Mutation
  • Respiration

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

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