Mitochondrial biogenesis for the treatment of spinal cord injury

Epiphani C. Simmons, Natalie E. Scholpa, Joshua D. Crossman, Rick G. Schnellmann

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Spinal cord injury (SCI) is characterized by neuroinflammation, vascular disruption, ischemia, and disturbed mitochondrial homeostasis. The resulting mitochondrial dysfunction propagates loss of cellular functions, calcium overload, and oxidative stress, all of which contribute to neuronal cell death and functional impairments. Recent evidence supports pharmacological induction of mitochondrial biogenesis (MB) as an effective approach to decrease mitochondrial dysfunction and secondary injury progression. MB is a multifaceted process involving the integration of highly regulated transcriptional events, altered mitochondrial morphology and dynamics, lipid membrane and protein synthesis, and production of mitochondrial DNA. This chapter provides an overview of key aspects of mitochondrial dysfunction following SCI, and the impact of cell type-specific MB in neurons, endothelial cells, and astrocytes. Also discussed are studies documenting a variety of targets capable of MB induction, modulation of mitochondrial dysfunction, and pathological and functional improvements post-SCI.

Original languageEnglish (US)
Title of host publicationDiagnosis and Treatment of Spinal Cord Injury
PublisherElsevier
Pages359-372
Number of pages14
ISBN (Electronic)9780128224984
ISBN (Print)9780128224991
DOIs
StatePublished - Jan 1 2022

Keywords

  • Astrocytes
  • Endothelial cells
  • Mitochondrial biogenesis
  • Mitochondrial dynamics
  • Mitochondrial dysfunction
  • Neuroinflammation
  • Neurons
  • Spinal cord injury

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience

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