Minireview immunomodulation by cocaine - A neuroendocrine mediated response

Bernhard Watzl; Ronald R. Watson

doi:10.1016/0024-3205(90)90331-K

Minireview immunomodulation by cocaine - A neuroendocrine mediated response

Bernhard Watzl, Ronald R. Watson

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Cocaine acts directly on lymphoid cells and indirectly modulates the immune response by affecting the level of neuroendocrine hormones. In vitro, very high concentrations of cocaine inhibit different immune responses, while plasma levels following cocaine use have no effect. The results of the few published in vivo studies are contradictory, showing stimulatory, suppressive or no effect on lymphoid cells. The indirect effects of cocaine on the immune system could be mediated by ACTH, beta-endorphin and corticosterone. Anorectic effect associated with nutritional deficiencies of drug users could additionally affect the immune response by cocaine.

Original language	English (US)
Pages (from-to)	1319-1329
Number of pages	11
Journal	Life Sciences
Volume	46
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(90)90331-K
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(90)90331-K

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title = "Minireview immunomodulation by cocaine - A neuroendocrine mediated response",

abstract = "Cocaine acts directly on lymphoid cells and indirectly modulates the immune response by affecting the level of neuroendocrine hormones. In vitro, very high concentrations of cocaine inhibit different immune responses, while plasma levels following cocaine use have no effect. The results of the few published in vivo studies are contradictory, showing stimulatory, suppressive or no effect on lymphoid cells. The indirect effects of cocaine on the immune system could be mediated by ACTH, beta-endorphin and corticosterone. Anorectic effect associated with nutritional deficiencies of drug users could additionally affect the immune response by cocaine.",

author = "Bernhard Watzl and Watson, {Ronald R.}",

note = "Funding Information: Supported by Carole Burke.",

year = "1990",

doi = "10.1016/0024-3205(90)90331-K",

language = "English (US)",

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pages = "1319--1329",

journal = "Life Sciences",

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T1 - Minireview immunomodulation by cocaine - A neuroendocrine mediated response

AU - Watzl, Bernhard

AU - Watson, Ronald R.

N1 - Funding Information: Supported by Carole Burke.

PY - 1990

Y1 - 1990

N2 - Cocaine acts directly on lymphoid cells and indirectly modulates the immune response by affecting the level of neuroendocrine hormones. In vitro, very high concentrations of cocaine inhibit different immune responses, while plasma levels following cocaine use have no effect. The results of the few published in vivo studies are contradictory, showing stimulatory, suppressive or no effect on lymphoid cells. The indirect effects of cocaine on the immune system could be mediated by ACTH, beta-endorphin and corticosterone. Anorectic effect associated with nutritional deficiencies of drug users could additionally affect the immune response by cocaine.

AB - Cocaine acts directly on lymphoid cells and indirectly modulates the immune response by affecting the level of neuroendocrine hormones. In vitro, very high concentrations of cocaine inhibit different immune responses, while plasma levels following cocaine use have no effect. The results of the few published in vivo studies are contradictory, showing stimulatory, suppressive or no effect on lymphoid cells. The indirect effects of cocaine on the immune system could be mediated by ACTH, beta-endorphin and corticosterone. Anorectic effect associated with nutritional deficiencies of drug users could additionally affect the immune response by cocaine.

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JO - Life Sciences

JF - Life Sciences

IS - 19

ER -

Minireview immunomodulation by cocaine - A neuroendocrine mediated response

Abstract

ASJC Scopus subject areas

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