Minimalistic graphical presentation approach for total syntheses

Kevin A. Scott; Jeffrey R. Groch; Jianhua Bao; Christopher M. Marshall; Rachel A. Allen; Steven J. Nick; Nicholas R. Lauta; Ryan E. Williams; Munaum H. Qureshi; Michael D. Delost; Jon T. Njardarson

doi:10.1016/j.tet.2022.133062

Minimalistic graphical presentation approach for total syntheses

Kevin A. Scott
, Jeffrey R. Groch
, Jianhua Bao
, Christopher M. Marshall
, Rachel A. Allen
, Steven J. Nick
, Nicholas R. Lauta
, Ryan E. Williams
, Munaum H. Qureshi
, Michael D. Delost
, Jon T. Njardarson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report a single image minimalistic presentation format for total syntheses, wherein on the foundation of a color-coded synthetic step/complexity chart are displayed the structure of the target molecule along with five key analysis parameters (total number of steps = TNS, longest linear sequence = LLS, oxidation reduction steps = ORS, protecting group steps = PGS and productive steps = PS percentage) for the synthetic blueprint. This purpose of this concise communication format is to enable rapid viewing and comparisons of target syntheses for the benefit of teaching, studying, and mastering synthetic organic chemistry.

Original language	English (US)
Article number	133062
Journal	Tetrahedron
Volume	126
DOIs	https://doi.org/10.1016/j.tet.2022.133062
State	Published - Nov 5 2022
Externally published	Yes

Keywords

Analysis
Complexity
Longest linear sequence
Productive step
Total synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2022.133062

Cite this

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title = "Minimalistic graphical presentation approach for total syntheses",

abstract = "We report a single image minimalistic presentation format for total syntheses, wherein on the foundation of a color-coded synthetic step/complexity chart are displayed the structure of the target molecule along with five key analysis parameters (total number of steps = TNS, longest linear sequence = LLS, oxidation reduction steps = ORS, protecting group steps = PGS and productive steps = PS percentage) for the synthetic blueprint. This purpose of this concise communication format is to enable rapid viewing and comparisons of target syntheses for the benefit of teaching, studying, and mastering synthetic organic chemistry.",

keywords = "Analysis, Complexity, Longest linear sequence, Productive step, Total synthesis",

author = "Scott, \{Kevin A.\} and Groch, \{Jeffrey R.\} and Jianhua Bao and Marshall, \{Christopher M.\} and Allen, \{Rachel A.\} and Nick, \{Steven J.\} and Lauta, \{Nicholas R.\} and Williams, \{Ryan E.\} and Qureshi, \{Munaum H.\} and Delost, \{Michael D.\} and Njardarson, \{Jon T.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = nov,

day = "5",

doi = "10.1016/j.tet.2022.133062",

language = "English (US)",

volume = "126",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Minimalistic graphical presentation approach for total syntheses

AU - Scott, Kevin A.

AU - Groch, Jeffrey R.

AU - Bao, Jianhua

AU - Marshall, Christopher M.

AU - Allen, Rachel A.

AU - Nick, Steven J.

AU - Lauta, Nicholas R.

AU - Williams, Ryan E.

AU - Qureshi, Munaum H.

AU - Delost, Michael D.

AU - Njardarson, Jon T.

PY - 2022/11/5

Y1 - 2022/11/5

N2 - We report a single image minimalistic presentation format for total syntheses, wherein on the foundation of a color-coded synthetic step/complexity chart are displayed the structure of the target molecule along with five key analysis parameters (total number of steps = TNS, longest linear sequence = LLS, oxidation reduction steps = ORS, protecting group steps = PGS and productive steps = PS percentage) for the synthetic blueprint. This purpose of this concise communication format is to enable rapid viewing and comparisons of target syntheses for the benefit of teaching, studying, and mastering synthetic organic chemistry.

AB - We report a single image minimalistic presentation format for total syntheses, wherein on the foundation of a color-coded synthetic step/complexity chart are displayed the structure of the target molecule along with five key analysis parameters (total number of steps = TNS, longest linear sequence = LLS, oxidation reduction steps = ORS, protecting group steps = PGS and productive steps = PS percentage) for the synthetic blueprint. This purpose of this concise communication format is to enable rapid viewing and comparisons of target syntheses for the benefit of teaching, studying, and mastering synthetic organic chemistry.

KW - Analysis

KW - Complexity

KW - Longest linear sequence

KW - Productive step

KW - Total synthesis

UR - https://www.scopus.com/pages/publications/85139822858

UR - https://www.scopus.com/pages/publications/85139822858#tab=citedBy

U2 - 10.1016/j.tet.2022.133062

DO - 10.1016/j.tet.2022.133062

M3 - Article

AN - SCOPUS:85139822858

SN - 0040-4020

VL - 126

JO - Tetrahedron

JF - Tetrahedron

M1 - 133062

ER -

Minimalistic graphical presentation approach for total syntheses

Abstract

Keywords

ASJC Scopus subject areas

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