Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement

Alexandre R. Tumlinson; Lida P. Hariri; Urs Utzinger; Jennifer K. Barton

doi:10.1364/AO.43.000113

Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement

Alexandre R. Tumlinson, Lida P. Hariri, Urs Utzinger, Jennifer K. Barton

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides ∼18-μm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo.

Original language	English (US)
Pages (from-to)	113-121
Number of pages	9
Journal	Applied optics
Volume	43
Issue number	1
DOIs	https://doi.org/10.1364/AO.43.000113
State	Published - Jan 1 2004

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

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AB - We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides ∼18-μm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo.

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Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement

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