Abstract
We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.
Original language | English (US) |
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Pages (from-to) | 6121-6125 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 23 |
Issue number | 15 |
DOIs | |
State | Published - Aug 6 2021 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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CCDC 2087417: Experimental Crystal Structure Determination
Delost, M. D. (Contributor) & Njardarson, J. T. (Contributor), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc28241k, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc28241k&sid=DataCite
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CCDC 2092036: Experimental Crystal Structure Determination
Delost, M. D. (Contributor) & Njardarson, J. T. (Contributor), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc286y1h, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc286y1h&sid=DataCite
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