Serum from patients with carcinoma of the prostate were observed to possess a factor(s) capable of inhibiting the migration of allogeneic leukocytes in the direct leukocyte migration test. Maximum inhibitory activity was obtained with those sera possessing an elevated level of an as yet unidentified factor(s) in the α2-globulin fraction of the serum of these patients. The presence of such a factor(s) may prevent interaction between leukocyte-inhibiting factor sensitive cells and tumour cells and emphasizes the role of humoral inhibitory or ‘immunoregulatory’ factors, such as a α2-globulin, on immunologic responses as blastogenesis and inhibition of leukocyte migration, as potential abrogators of mechanisms of host-resistance, e.g., immunologic surveillance.
- Humoral immunoregulatory factor(s)
- Inhibition of leukocyte migration
- Prostatic cancer
ASJC Scopus subject areas
- Cancer Research