Migration-inhibitory effect of serum from patients with prostatic cancer

Richard J. Ablin; Gailon R. Bruns; Patrick D. Guinan; Irving M. Bush

doi:10.1159/000224982

Migration-inhibitory effect of serum from patients with prostatic cancer

Richard J. Ablin, Gailon R. Bruns, Patrick D. Guinan, Irving M. Bush

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Serum from patients with carcinoma of the prostate were observed to possess a factor(s) capable of inhibiting the migration of allogeneic leukocytes in the direct leukocyte migration test. Maximum inhibitory activity was obtained with those sera possessing an elevated level of an as yet unidentified factor(s) in the α2-globulin fraction of the serum of these patients. The presence of such a factor(s) may prevent interaction between leukocyte-inhibiting factor sensitive cells and tumour cells and emphasizes the role of humoral inhibitory or ‘immunoregulatory’ factors, such as a α2-globulin, on immunologic responses as blastogenesis and inhibition of leukocyte migration, as potential abrogators of mechanisms of host-resistance, e.g., immunologic surveillance.

Original language	English (US)
Pages (from-to)	423-428
Number of pages	6
Journal	Oncology (Switzerland)
Volume	30
Issue number	5
DOIs	https://doi.org/10.1159/000224982
State	Published - 1974
Externally published	Yes

Keywords

Humoral immunoregulatory factor(s)
Inhibition of leukocyte migration
Prostatic cancer
α2-Globulin

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1159/000224982

Cite this

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title = "Migration-inhibitory effect of serum from patients with prostatic cancer",

abstract = "Serum from patients with carcinoma of the prostate were observed to possess a factor(s) capable of inhibiting the migration of allogeneic leukocytes in the direct leukocyte migration test. Maximum inhibitory activity was obtained with those sera possessing an elevated level of an as yet unidentified factor(s) in the α2-globulin fraction of the serum of these patients. The presence of such a factor(s) may prevent interaction between leukocyte-inhibiting factor sensitive cells and tumour cells and emphasizes the role of humoral inhibitory or {\textquoteleft}immunoregulatory{\textquoteright} factors, such as a α2-globulin, on immunologic responses as blastogenesis and inhibition of leukocyte migration, as potential abrogators of mechanisms of host-resistance, e.g., immunologic surveillance.",

keywords = "Humoral immunoregulatory factor(s), Inhibition of leukocyte migration, Prostatic cancer, α2-Globulin",

author = "Ablin, {Richard J.} and Bruns, {Gailon R.} and Guinan, {Patrick D.} and Bush, {Irving M.}",

year = "1974",

doi = "10.1159/000224982",

language = "English (US)",

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pages = "423--428",

journal = "Oncology (Switzerland)",

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TY - JOUR

T1 - Migration-inhibitory effect of serum from patients with prostatic cancer

AU - Ablin, Richard J.

AU - Bruns, Gailon R.

AU - Guinan, Patrick D.

AU - Bush, Irving M.

PY - 1974

Y1 - 1974

N2 - Serum from patients with carcinoma of the prostate were observed to possess a factor(s) capable of inhibiting the migration of allogeneic leukocytes in the direct leukocyte migration test. Maximum inhibitory activity was obtained with those sera possessing an elevated level of an as yet unidentified factor(s) in the α2-globulin fraction of the serum of these patients. The presence of such a factor(s) may prevent interaction between leukocyte-inhibiting factor sensitive cells and tumour cells and emphasizes the role of humoral inhibitory or ‘immunoregulatory’ factors, such as a α2-globulin, on immunologic responses as blastogenesis and inhibition of leukocyte migration, as potential abrogators of mechanisms of host-resistance, e.g., immunologic surveillance.

AB - Serum from patients with carcinoma of the prostate were observed to possess a factor(s) capable of inhibiting the migration of allogeneic leukocytes in the direct leukocyte migration test. Maximum inhibitory activity was obtained with those sera possessing an elevated level of an as yet unidentified factor(s) in the α2-globulin fraction of the serum of these patients. The presence of such a factor(s) may prevent interaction between leukocyte-inhibiting factor sensitive cells and tumour cells and emphasizes the role of humoral inhibitory or ‘immunoregulatory’ factors, such as a α2-globulin, on immunologic responses as blastogenesis and inhibition of leukocyte migration, as potential abrogators of mechanisms of host-resistance, e.g., immunologic surveillance.

KW - Humoral immunoregulatory factor(s)

KW - Inhibition of leukocyte migration

KW - Prostatic cancer

KW - α2-Globulin

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Migration-inhibitory effect of serum from patients with prostatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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