TY - JOUR
T1 - Microwave-induced thermoacoustic imaging model for potential breast cancer detection
AU - Wang, Xiong
AU - Bauer, Daniel R.
AU - Witte, Russell
AU - Xin, Hao
PY - 2012
Y1 - 2012
N2 - In this study, we develop a complete microwave-induced thermoacoustic imaging (TAI) model for potential breast cancer imaging application. Acoustic pressures generated by different breast tissue targets are investigated by finite-difference time-domain simulations of the entire TAI process including the feeding antenna, matching mechanism, fluidic environment, 3-D breast model, and acoustic transducer. Simulation results achieve quantitative relationships between the input microwave peak power and the resulting specific absorption rate as well as the output acoustic pressure. Microwave frequency dependence of the acoustic signals due to different breast tissues is established across a broadband frequency range (2.3-12GHz), suggesting key advantages of spectroscopic TAI compare to TAI at a single frequency. Reconstructed thermoacoustic images are consistent with the modeling results. This model will contribute to design, optimization, and safety evaluation of microwave-induced TAI and spectroscopy.
AB - In this study, we develop a complete microwave-induced thermoacoustic imaging (TAI) model for potential breast cancer imaging application. Acoustic pressures generated by different breast tissue targets are investigated by finite-difference time-domain simulations of the entire TAI process including the feeding antenna, matching mechanism, fluidic environment, 3-D breast model, and acoustic transducer. Simulation results achieve quantitative relationships between the input microwave peak power and the resulting specific absorption rate as well as the output acoustic pressure. Microwave frequency dependence of the acoustic signals due to different breast tissues is established across a broadband frequency range (2.3-12GHz), suggesting key advantages of spectroscopic TAI compare to TAI at a single frequency. Reconstructed thermoacoustic images are consistent with the modeling results. This model will contribute to design, optimization, and safety evaluation of microwave-induced TAI and spectroscopy.
KW - Breast cancer detection
KW - microwave spectroscopy
KW - safety evaluation
KW - thermoacoustic imaging (TAI)
UR - http://www.scopus.com/inward/record.url?scp=84866526791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866526791&partnerID=8YFLogxK
U2 - 10.1109/TBME.2012.2210218
DO - 10.1109/TBME.2012.2210218
M3 - Article
C2 - 22851231
AN - SCOPUS:84866526791
SN - 0018-9294
VL - 59
SP - 2782
EP - 2791
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 10
M1 - 14
ER -