Microtubules in insulin action: what's on the tube?

Skylar R. Batty, Paul R. Langlais

Research output: Contribution to journalReview articlepeer-review

Abstract

Microtubules (MT) have a role in the intracellular response to insulin stimulation and subsequent glucose transport by glucose transporter 4 (GLUT4), which resides in specialized storage vesicles that travel through the cell. Before GLUT4 is inserted into the plasma membrane for glucose transport, it undergoes complex trafficking through the cell via the integration of cytoskeletal networks. In this review, we highlight the importance of MT elements in insulin action in adipocytes through a summary of MT depolymerization studies, MT-based GLUT4 movement, molecular motor proteins involved in GLUT4 trafficking, as well as MT-related phenomena in response to insulin and links between insulin action and MT-associated proteins.

Original languageEnglish (US)
Pages (from-to)776-789
Number of pages14
JournalTrends in Endocrinology and Metabolism
Volume32
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • GLUT4
  • glucose transport
  • insulin
  • microtubules

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint

Dive into the research topics of 'Microtubules in insulin action: what's on the tube?'. Together they form a unique fingerprint.

Cite this